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. 1973 Jun 22;180(4092):1295-7.
doi: 10.1126/science.180.4092.1295.

Axonal transport of dopamine- -hydroxylase by human sural nerves in vitro

S Brimijoin, P Capek, P J Dyck

Axonal transport of dopamine- -hydroxylase by human sural nerves in vitro

S Brimijoin et al. Science. .

Abstract

Dopamine-beta-hydroxylase activity accumulated above a ligature on biopsy samples of normal human sural nerves incubated in vitro. The rate of accumulation indicated that this enzyme was transported distally at a velocity of 2 millimeters per hour. Axoplasmic transport of dopamine-beta-hydroxylase was greatly reduced in sural nerves from a few patients with peripheral neuropathies.

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