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Comment

. 2025 Nov 13;390(6774):676-677.

doi: 10.1126/science.aec3823. Epub 2025 Nov 13.

Programmable DNA insertion in native gut bacteria

Amandine Maire¹, David Bikard¹

Affiliations

PMID: 41232012
DOI: 10.1126/science.aec3823

Comment

Programmable DNA insertion in native gut bacteria

Amandine Maire et al. Science. 2025.

. 2025 Nov 13;390(6774):676-677.

doi: 10.1126/science.aec3823. Epub 2025 Nov 13.

Authors

Amandine Maire¹, David Bikard¹

Affiliation

¹ Institut Pasteur, Université Paris Cité, CNRS UMR 3525, Synthetic Biology, Paris, France.

PMID: 41232012
DOI: 10.1126/science.aec3823

Abstract

A gene-editing approach enables modification of bacteria within the mouse gut.

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Metagenomic editing of commensal bacteria in vivo using CRISPR-associated transposases.
Gelsinger DR, Ronda C, Ma J, Kar OB, Edwards M, Huang Y, Mavros CF, Sun Y, Perdue T, Vo PL, Ivanov II, Sternberg SH, Wang HH. Gelsinger DR, et al. Science. 2025 Nov 13;390(6774):eadx7604. doi: 10.1126/science.adx7604. Epub 2025 Nov 13. Science. 2025. PMID: 41231980 Free PMC article.

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