Emerging role and interplay of programmed cell death in endometritis: Insights into mechanisms and therapeutic targets

Abstract

Endometritis is the inflammation of the endometrial lining, frequently linked to pelvic pain. Endometritis is significantly associated with postpartum problems, including infertility. Programmed cell death (PCD) is a genetically regulated mechanism of autonomic and regulated cell death that preserves homeostasis and promotes development. PCD, which includes apoptosis, pyroptosis, autophagy, ferroptosis, and necroptosis, is essential in the pathogenesis of reproductive diseases, including endometritis. Despite the limited study on PCD in endometritis, it is essential to identify important molecules and comprehend their regulatory functions for effective disease prevention and management. This review delineates the different types of PCD and their interactions in endometritis. It also evaluates the progress in PCD research pertaining to endometritis. The objective is to create a basis for subsequent investigations into the function and interaction of PCD in endometritis. We anticipate that this study will facilitate the exploration of novel PCD targets for endometritis treatment, hence encouraging comprehensive research.

Keywords: Apoptosis; Endometritis; Ferroptosis; Necroptosis; Pyroptosis.