[The mechanism of Ferroptosis in Aplastic Anemia --Review]
- PMID: 41234111
- DOI: 10.19746/j.cnki.issn.1009-2137.2025.05.044
[The mechanism of Ferroptosis in Aplastic Anemia --Review]
Abstract
Ferroptosis initiates membrane oxidative damage through lipid peroxidation and iron accumulation, and accumulates reactive oxygen species (ROS) during aplastic anemia (AA). Ferroptosis induces damage and apoptosis of hematopoietic stem/progenitor cells, mesenchymal stem cells, blood cells, and T lymphocytes through various pathways, inhibits bone marrow hematopoiesis, damages bone marrow microenvironment, exacerbates immune imbalance, leading to bone marrow failure and disease progression. Therefore, further exploring the ferroptosis mechanism in AA can help clarify the pathogenesis of disease and provide new research ideas and directions for the treatment of AA.
题目: 铁死亡在再生障碍性贫血中的作用机制.
摘要: 在再生障碍性贫血病程中，铁死亡通过脂质过氧化和铁积累启动膜氧化损伤，积累活性氧，并通过多种途径诱导造血干/祖细胞、间充质干细胞、血细胞和T淋巴细胞损伤和凋亡，抑制骨髓造血、破坏骨髓微环境、加剧免疫失衡，导致骨髓造血功能衰竭，疾病进展。进一步深入探讨铁死亡机制在再生障碍性贫血中的作用，有助于阐明疾病发病机理，为治疗再生障碍性贫血提供新的研究思路和方向。.
Keywords: aplastic anemia; ferroptosis; oxidative stress; mechanism.
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