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. 2025 Sep 18:66:77-79.
doi: 10.1016/j.jdcr.2025.08.033. eCollection 2025 Dec.

Multinucleate cell angiohistiocytoma

Connor A Sheehan  1 , Jayci G Rhein  1 , Jordan T Hyde  2 , Jason B Lee  2 , Sylvia Hsu  1
Affiliations

Multinucleate cell angiohistiocytoma

Connor A Sheehan et al. JAAD Case Rep. .
No abstract available

Keywords: multinucleate cell angiohistiocytoma.

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Conflict of interest statement

None disclosed.

Figures

Fig 1
Fig 1
Two erythematous papules on the right dorsal hand.
Fig 2
Fig 2
Erythematous papule on the left dorsal hand.
Fig 3
Fig 3
Dermal fibrosis and dilated vasculature with incidental procedural hemorrhage (H&E 5.6×).
Fig 4
Fig 4
Thickened collagen bundles and dilated vessels with increased interstitial fibroblasts (H&E 15.6×).
Fig 5
Fig 5
Characteristic multinucleated cells with scalloped borders (H&E 29.1×).
See this image and copyright information in PMC

References

    1. Ross C.L., Chung J., Ross N.A., Lee J.B. Generalized multinucleate cell angiohistiocytoma: histopathological and immunohistochemical analyses of 10 lesions. Am J Dermatopathol. 2021;43(12):976–979. doi: 10.1097/DAD.0000000000001954. - DOI - PubMed
    1. Shapiro P.E., Nova M.P., Rosmarin L.A., Halperin A.J. Multinucleate cell angiohistiocytoma: a distinct entity diagnosable by clinical and histologic features. J Am Acad Dermatol. 1994;30(3):417–422. doi: 10.1016/s0190-9622(94)70049-4. - DOI - PubMed
    1. Taibo A., Padin C.P., Losada J.D.P., Fonseca E. Treatment options for multinucleate cell angiohistiocytoma: a case series and review of the literature. J Cutan Med Surg. 2023;27(3):219–225. doi: 10.1177/12034754231163539. - DOI - PubMed
    1. Jia Q.N., Qiao J., Qu T. Generalized multinucleate cell angiohistiocytoma with possible origin from fibroblasts: a clinicopathological study of 15 cases. J Dermatol. 2021;48(1):114–119. doi: 10.1111/1346-8138.15610. - DOI - PubMed
    1. Frew J.W. Multinucleate cell angiohistiocytoma: clinicopathological correlation of 142 cases with insights into etiology and pathogenesis. Am J Dermatopathol. 2015;37(3):222–228. doi: 10.1097/DAD.0000000000000075. - DOI - PubMed

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