Genetic susceptibility in early-onset melanoma: An observational Greek cohort study

Affiliations

¹ Skin Cancer Center, Department of Dermatology, Eberhard Karls University of Tuebingen, Tuebingen, Germany.
² Department of Dermatology, University of Athens Medical School, Andreas Syggros Hospital, Athens, Greece.
³ Biomedical Research Foundation of the Academy of Athens, Athens, Greece.
⁴ Department of Histopathology, University of Athens Medical School, Andreas Syggros Hospital, Athens, Greece.
⁵ First Department of Medicine, University of Athens Medical School, Laikon Hospital, Athens, Greece.
⁶ Department of Genetic Medicine and Development, Medical School, University of Geneva, Geneva, Switzerland.
⁷ Laboratory of Medical Genetics, University of Athens Medical School, Athens, Greece.

Eftychia Chatziioannou et al. J Eur Acad Dermatol Venereol. 2025.

. 2025 Nov 14.

doi: 10.1111/jdv.70161. Online ahead of print.

¹ Skin Cancer Center, Department of Dermatology, Eberhard Karls University of Tuebingen, Tuebingen, Germany.
² Department of Dermatology, University of Athens Medical School, Andreas Syggros Hospital, Athens, Greece.
³ Biomedical Research Foundation of the Academy of Athens, Athens, Greece.
⁴ Department of Histopathology, University of Athens Medical School, Andreas Syggros Hospital, Athens, Greece.
⁵ First Department of Medicine, University of Athens Medical School, Laikon Hospital, Athens, Greece.
⁶ Department of Genetic Medicine and Development, Medical School, University of Geneva, Geneva, Switzerland.
⁷ Laboratory of Medical Genetics, University of Athens Medical School, Athens, Greece.

No abstract available

Keywords: genetic testing; genetics; medical oncology; melanoma; mutation; skin neoplasms.

References

1. Silva JH, de Sá BC, Ávila ALR, Landman G, Neto JPD. Atypical mole syndrome and dysplastic nevi: identification of populations at risk for developing melanoma ‐ review article. Clinics (Sao Paulo). 2011;66(3):493.
1. Maas EJ, Wallingford CK, De Bortoli E, Primiero C, Freeman NP, Smit DJ, et al. Prevalence of high‐risk melanoma variants in early‐onset and/or multiple primary melanoma in an Australian cohort. J Eur Acad Dermatol Venereol. 2025;39: e950–e955.
1. Tsao H, Zhang X, Kwitkiwski K, Finkelstein DM, Sober AJ, Haluska FG. Low prevalence of germline CDKN2A and CDK4 mutations in patients with early‐onset melanoma. Arch Dermatol. 2000;136(9):1118–1122.
1. Funchain P, Ni Y, Heald B, Bungo B, Arbesman M, Behera TR, et al. Germline cancer susceptibility in individuals with melanoma. J Am Acad Dermatol. 2024;91(2):265–272.
1. Kypreou K, Stergiopoulou A, Plaka M, Befon A, Chardalia V, Stratigos IA, et al. Targeted sequencing analysis of loci implicated in familial melanoma in a Greek cohort. J Eur Acad Dermatol Venereol. 2024;38(6):e525–e527.