Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1973 Aug 1;138(2):473-8.
doi: 10.1084/jem.138.2.473.

Hapten-specific stimulation of secondary B cells independent of T cells

N R Klinman, R A Doughty

Hapten-specific stimulation of secondary B cells independent of T cells

N R Klinman et al. J Exp Med. .

Abstract

Treatment of spleen cell suspensions from immunized mice with anti-theta serum and complement before transfer to nonimmune irradiated recipients reduced the degree of in vitro stimulation by hapten-homologous carrier complexes by 90%, but did not decrease at all the number of isolated precursor cells stimulated by hapten on heterologous carriers. Thus, secondary B cells can be stimulated by low concentrations of multiply substituted hapten-carrier complexes in the apparent complete absence of specific T cells.

PubMed Disclaimer

References

    1. Eur J Immunol. 1971 Jan;1(1):10-7 - PubMed
    1. J Exp Med. 1965 Jun 1;121:873-88 - PubMed
    1. J Immunol. 1968 Feb;100(2):384-94 - PubMed
    1. J Exp Med. 1968 Apr 1;127(4):717-30 - PubMed
    1. J Exp Med. 1971 May 1;133(5):963-72 - PubMed