Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2025 Jul-Dec;19(2):393-395.
doi: 10.4103/ajts.ajts_57_23. Epub 2024 Apr 16.

A case of allogeneic peripheral blood stem cell in a paroxysmal nocturnal hemoglobinuria patient from a COVID-positive donor: Managing the unpreventable

Mohit Chowdhry  1 , Prachi Singh  2 , S Minu Lekshmi  1 , Uday Kumar Thakur  1 , Shishir Seth  2
Affiliations
Case Reports

A case of allogeneic peripheral blood stem cell in a paroxysmal nocturnal hemoglobinuria patient from a COVID-positive donor: Managing the unpreventable

Mohit Chowdhry et al. Asian J Transfus Sci. 2025 Jul-Dec.

Abstract

Paroxysmal nocturnal hemoglobinuria (PNH) is a rare, acquired disease caused by clonal expansion of one or more hematopoietic stem cell lines due to a somatic mutation of the phosphatidylinositol glycan anchor gene. Peripheral blood stem cell (PBSC) harvest is a high-risk procedure and the major concern was regarding the development of COVID infection in the recipient. Herein, we describe an inevitable case of PBSC harvest in a PNH patient who was already started on myeloablation and where the donor became positive 1 day before the harvest. Considering the risk-benefit ratio and the need for elaborate arrangements, the initial plan for bone marrow harvesting was changed to PBSC, and hence, the harvest was performed in a COVID-designated unit. No features of graft versus host disease (GVHD) were observed in the patient. The patient was examined for signs and symptoms of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and there was no evidence of any infection after the procedure. The weekly analysis of the same was done for 1 month after PBSC and the SARS-CoV-2 status remained negative. The authors opine that PBSC from SARS-CoV-2 can be performed safely in some unpreventable situations.

Keywords: COVID; paroxysmal nocturnal hemoglobinuria; peripheral blood stem cell.

PubMed Disclaimer

Conflict of interest statement

There are no conflicts of interest.

References

    1. WHO Coronavirus (COVID-19) Dashboard. [Last accessed on 2022 Dec 14]. Available from:https://covid19.who.int .
    1. [Last accessed on 2021 Nov 30]. Available from:https://www.mohfw.gov.in/pdf/GuidelinesforInternationalarrivalsdated30th... .
    1. Ljungman P, Mikulska M, de la Camara R, Basak GW, Chabannon C, Corbacioglu S, et al. The challenge of COVID-19 and hematopoietic cell transplantation;EBMT recommendations for management of hematopoietic cell transplant recipients, their donors, and patients undergoing CAR T-cell therapy. Bone Marrow Transplant. 2020;55:2071–6. - PMC - PubMed
    1. Leclerc M, Fourati S, Menouche D, Challine D, Maury S. Allogeneic haematopoietic stem cell transplantation from SARS-CoV-2 positive donors. Lancet Haematol. 2021;8:e167–9. - PMC - PubMed
    1. Anurathapan U, Apiwattanakul N, Pakakasama S, Pongphitcha P, Thitithanyanont A, Pasomsub E, et al. Hematopoietic stem cell transplantation from an infected SARS-CoV2 donor sibling. Bone Marrow Transplant. 2020;55:2359–60. - PMC - PubMed

Publication types

LinkOut - more resources