Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2025 Nov 15:10:20250033.
doi: 10.2490/prm.20250033. eCollection 2025.

Skeletal Muscle Mass and Physical Function during Neoadjuvant Therapy for Pancreatic Cancer: A Multimodal Prehabilitation Approach

Ayamitsu Maeda  1 , Shunji Takashima  1   2 , Tetsuyuki Nagafusa  1   3 , Katsuya Yamauchi  1   3
Affiliations

Skeletal Muscle Mass and Physical Function during Neoadjuvant Therapy for Pancreatic Cancer: A Multimodal Prehabilitation Approach

Ayamitsu Maeda et al. Prog Rehabil Med. .
No abstract available

Keywords: chemoradiotherapy; pancreatic neoplasm; physical capability; striated muscles.

PubMed Disclaimer

Conflict of interest statement

CONFLICTS OF INTEREST: The authors declare no conflict of interest.

Figures

Fig. 1.
Fig. 1.
Timeline of multimodal interventions during hospitalization and follow-up. Chronological summary of physiotherapy, nutritional interventions, chemoradiotherapy, and the surgical course.
Fig. 2.
Fig. 2.
Trends in energy intake, protein intake, and transthyretin levels during hospitalization. Grey bars, daily energy intake, green dashed line with open circles, protein intake; blue solid line with square markers, transthyretin level. Vertical axes: left Y-axis, energy intake; outer right Y-axis, protein intake; inner right Y-axis, transthyretin. Horizontal axis: X = 0, day of admission for CRT; T1, X + 4 to 9 days (first week of hospitalization); T2, X + 10 to 16 days; T3, X + 17 to 23 days; T4, X + 24 to 30 days; T5, X + 31 to 37 days (end of CRT and discharge).
Fig. 3.
Fig. 3.
Weekly step count during hospitalization and preoperative period. A progressive increase in the weekly step count was observed during hospitalization throughout the preoperative outpatient period. Dotted line, target of 5000 steps/day. Horizontal axis: X = 0, day of admission for CRT; T1, X + 4 to 9 days (first week of hospitalization); T2, X + 10 to 16 days; T3, X + 17 to 23 days; T4, X + 24 to 30 days; T5, X + 31 to 37 days; T6, X + 38 to 44 days (first outpatient week); T7, X + 45 to 51 days; T8, X + 52 to 58 days (week before surgery).
See this image and copyright information in PMC

References

    1. Takahashi S,Ohno I,Ikeda M,Konishi M,Kobayashi T,Akimoto T,Kojima M,Morinaga S,Toyama H,Shimizu Y,Miyamoto A,Tomikawa M,Takakura N,Takayama W,Hirano S,Otsubo T,Nagino M,Kimura W,Sugimachi K,Uesaka K: Neoadjuvant S-1 with concurrent radiotherapy followed by surgery for borderline resectable pancreatic cancer: a phase II open-label multicenter prospective trial (JASPAC05). Ann Surg 2022;276:e510–e517. 10.1097/SLA.0000000000004535 - DOI - PubMed
    1. Paiella S,Azzolina D,Trestini I,Malleo G,Nappo G,Ricci C,Ingaldi C,Vacca PG,De Pastena M,Secchettin E,Zamboni G,Maggino L,Corciulo MA,Sandini M,Cereda M,Capretti G,Casadei R,Bassi C,Mansueto G,Gregori D,Milella M,Zerbi A,Gianotti L,Salvia R: Body composition parameters, immunonutritional indexes, and surgical outcome of pancreatic cancer patients resected after neoadjuvant therapy: a retrospective, multicenter analysis. Front Nutr 2023;10:1065294. 10.3389/fnut.2023.1065294 - DOI - PMC - PubMed
    1. Matsumoto M,Shirai Y,Tsunematsu M,Okui N,Gocho T,Onda S,Furukawa K,Haruki K,Uwagawa T,Ikegami T: Changes in skeletal muscle volume during preoperative chemotherapy affect the outcome of pancreatic cancer. Am Surg 2025;91:115–125. 10.1177/00031348241278021 - DOI - PubMed
    1. Nakajima H,Yokoyama Y,Inoue T,Nagaya M,Mizuno Y,Kayamoto A,Nishida Y,Nagino M: How many steps per day are necessary to prevent postoperative complications following hepato-pancreato-biliary surgeries for malignancy? Ann Surg Oncol 2020;27:1387–1397. 10.1245/s10434-020-08218-x - DOI - PubMed
    1. Cos H,Zárate Rodríguez JG,Srivastava R,Bewley A,Raper L,Li D,Dai R,Williams GA,Fields RC,Hawkins WG,Lu C,Sanford DE,Hammill CW: 4,300 steps per day prior to surgery are associated with improved outcomes after pancreatectomy. HPB (Oxford) 2023;25:91–99. 10.1016/j.hpb.2022.09.011 - DOI - PubMed