Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1977 Dec;12(6):748-50.
doi: 10.1128/AAC.12.6.748.

Methadone: antimicrobial activity and interaction with antibiotics

J N Sheagren, I S Barsoum, M Y Lin

Methadone: antimicrobial activity and interaction with antibiotics

J N Sheagren et al. Antimicrob Agents Chemother. 1977 Dec.

Abstract

We studied the effect of methadone, alone and in combination with antimicrobial agents, on two strains each of Staphylococcus aureus, Pseudomonas aeruginosa, and Serratia marcescens isolated from blood streams of parenteral drug abusers with bacterial endocarditis. Methadone has its own antibacterial effect, although at supraphysiological concentrations, and is even synergistic with antimicrobial agents against some organisms. Thus, methadone does not interfere with the antibacterial effects of antibiotics in vitro.

PubMed Disclaimer

References

    1. Arch Intern Med. 1975 Dec;135(12):1555-61 - PubMed
    1. Ann Intern Med. 1976 Jan;84(1):29-35 - PubMed
    1. Appl Microbiol. 1970 Jul;20(1):46-53 - PubMed
    1. N Engl J Med. 1976 May 13;294(20):1104-6 - PubMed
    1. Life Sci. 1975 Jul 15;17(2):247-51 - PubMed

MeSH terms

LinkOut - more resources