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. 2025 Oct 28.
doi: 10.1097/ICO.0000000000004034. Online ahead of print.

A New Standardized Protocol for Linear and Volumetric Measurements in Osteo-Odonto-Keratoprosthesis

June Artaechevarria Artieda  1   2   3 , Tanya Trinh  1   2   3 , Luke Northey  1   2   3 , Shannon Webber  4 , Darryl Heaney  5 , Chi Man Vincent Siu  5 , Georges Hazan  5 , Gregory Moloney  6
Affiliations

A New Standardized Protocol for Linear and Volumetric Measurements in Osteo-Odonto-Keratoprosthesis

June Artaechevarria Artieda et al. Cornea. .

Abstract

Purpose: To evaluate the use of standardized computerized tomography (CT) scan protocols for monitoring osteo-odonto laminas in patients undergoing modified osteo-odonto-keratoprosthesis (OOKP).

Methods: This retrospective study included patients at Sydney Eye Hospital who underwent modified OOKP with temporalis fascial flap incorporation between 2016 and 2019. CT scans with linear and volumetric measurements monitored the lamina for resorption. Linear measurements on the frontal and nasal faces of the lamina were taken, and volumetric changes were analyzed using Vitrea software. Clinical outcomes, including visual acuity and lamina stability, were evaluated during follow-up.

Results: Four eyes from 4 patients were included with a mean follow-up of 80 months (range: 64-90 months). All patients achieved best-corrected visual acuity of 0.2 logarithm of the minimum angle resolution. Focal lamina resorption was detected in 1 patient at 3 years, requiring surgical repair. Volumetric analysis showed a decrease in lamina volume in 3 patients, with most reduction occurring within the first year (-5.35% to -13.04%). After that, volume stabilized. One patient showed no resorption at the final follow-up. No major complications were observed.

Conclusions: The standardized CT scan protocol with linear and volumetric analysis provides an effective method for the monitorization of the osteo-odonto laminas and facilitates early detection of lamina resorption in patients with OOKP.

Keywords: CT scan; Vitrea; laminar resorption; linear analysis; osteo-odonto-keratoprosthesis; volumetric analysis.

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Conflict of interest statement

The authors have no funding or conflicts of interest to disclose.

References

    1. Liu C, Paul B, Tandon R, et al. The osteo-odonto-keratoprosthesis (OOKP). Semin Ophthalmol. 2005;20:113–128.
    1. Falcinelli G, Falsini B, Taloni M, et al. Modified osteo-odonto-keratoprosthesis for treatment of corneal blindness: long-term anatomical and functional outcomes in 181 cases. Arch Ophthalmol. 2005;123:1319–1329.
    1. Hille K, Grabner G, Liu C, et al. Standards for modified osteoodontokeratoprosthesis (OOKP) surgery according to Strampelli and Falcinelli: the Rome-Vienna Protocol. Cornea. 2005;24:895–908.
    1. Iyer G, Srinivasan B, Agarwal S, et al. Laminar resorption in modified osteo-odonto-keratoprosthesis procedure: a cause for concern. Am J Ophthalmol. 2014;158:263–269.e2.
    1. Avadhanam VS, Chervenkoff JV, Zarei-Ghanavati M, et al. Clinical study of laminar resorption: part 1 - factors affecting laminar resorption. Ocul Surf. 2020;18:699–705.

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