No precision psychiatry without clinical precision

Ali Amad¹, Fabien D'Hondt^{2

3}, Mohamed Daoudi^{4

5}, Thomas Fovet²

Affiliations

¹ Univ. Lille, Inserm, CHU Lille, U1172 - LilNCog - Lille Neuroscience & Cognition, F-59000, Lille, France. ali.amad@chu-lille.fr.
² Univ. Lille, Inserm, CHU Lille, U1172 - LilNCog - Lille Neuroscience & Cognition, F-59000, Lille, France.
³ Centre national de ressources et de résilience (Cn2r), Lille, France.
⁴ Univ. Lille, CNRS, Centrale Lille, Institut Mines- Télécom, UMR 9189 CRIStAL, F-59000, Lille, France.
⁵ IMT Nord Europe, Institut Mines-Télécom, Centre for Digital Systems, Lille, France.

Ali Amad et al. Mol Psychiatry. 2025.

. 2025 Nov 17.

doi: 10.1038/s41380-025-03363-9. Online ahead of print.

Ali Amad¹, Fabien D'Hondt^{2

3}, Mohamed Daoudi^{4

5}, Thomas Fovet²

¹ Univ. Lille, Inserm, CHU Lille, U1172 - LilNCog - Lille Neuroscience & Cognition, F-59000, Lille, France. ali.amad@chu-lille.fr.
² Univ. Lille, Inserm, CHU Lille, U1172 - LilNCog - Lille Neuroscience & Cognition, F-59000, Lille, France.
³ Centre national de ressources et de résilience (Cn2r), Lille, France.
⁴ Univ. Lille, CNRS, Centrale Lille, Institut Mines- Télécom, UMR 9189 CRIStAL, F-59000, Lille, France.
⁵ IMT Nord Europe, Institut Mines-Télécom, Centre for Digital Systems, Lille, France.

No abstract available

Conflict of interest statement

Competing interests: The authors declare no competing interests.

1. Kas MJH, Penninx BWJH, Knudsen GM, Cuthbert B, Falkai P, Sachs GS, et al. Precision psychiatry roadmap: towards a biology-informed framework for mental disorders. Mol Psychiatry. 2025;30:3846–55.
1. Jermy BS, Glanville KP, Coleman JRI, Lewis CM, Vassos E. Exploring the genetic heterogeneity in major depression across diagnostic criteria. Mol Psychiatry. 2021;26:7337–45. - DOI - PubMed - PMC
1. Cai N, Revez JA, Adams MJ, Andlauer TFM, Breen G, Byrne EM, et al. Minimal phenotyping yields genome-wide association signals of low specificity for major depression. Nat Genet. 2020;52:437–47. - DOI - PubMed - PMC
1. Kendler KS. Toward a philosophical structure for psychiatry. AJP. 2005;162:433–40. - DOI
1. Leucht S, van Os J, Jäger M, Davis JM. Prioritization of psychopathological symptoms and clinical characterization in psychiatric diagnoses: a narrative review. JAMA Psychiatry. 2024;81:1149–58.