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Review
. 2025 Nov 10:2025:6926727.
doi: 10.1155/sci5/6926727. eCollection 2025.

Probiotics Supplementation in Tuberculosis: A Scoping Review

Tejaswini Baral  1 , Mohan K Manu  2 , Kavitha Saravu  3 , Chandrashekar Udyavara Kudru  4 , Jitendra Singh  5 , Chiranjay Mukhopadhyay  6 , Mahadev Rao  1 , Sonal Sekhar Miraj  1
Affiliations
Review

Probiotics Supplementation in Tuberculosis: A Scoping Review

Tejaswini Baral et al. Scientifica (Cairo). .

Abstract

This scoping review aims to synthesize the current clinical evidence on probiotics used in tuberculosis (TB). Systematic literature searches were conducted across PubMed, Scopus, and Embase databases to identify all studies using probiotics in TB. A total of six studies conducted between 2016 and 2023 were found and included in this review. All the studies incorporated probiotics supplementation not beyond the intensive phase of antitubercular therapy (ATT), ranging from three to eight weeks. Five out of six included studies focused on pulmonary TB. Probiotics alleviate adverse gastrointestinal and hepatic drug reactions, modulate gut microbiota, enhance barrier function, and influence immune responses. Therefore, probiotics are a potential adjunct therapy during the intensive phase of ATT. However, their long-term effects remain unexplored, highlighting the future research scope for well-designed longitudinal studies to explore their sustained benefits.

Keywords: antitubercular therapy; probiotics; tuberculosis.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
PRISMA flowchart.
Figure 2
Figure 2
Summary of the proposed mechanisms and clinical effects of probiotic supplements in TB from included clinical studies.
See this image and copyright information in PMC

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