Addition of metamizole to paracetamol at home after painful ambulatory arthroscopic shoulder surgery: A double-blind randomised controlled superiority trial

Affiliations

¹ From the Department of Anaesthesiology and Pain Medicine, Jessa Hospital, Hasselt (BS, NM, IC, JV, SE, KN, AN, JD), UHasselt, Faculty of Medicine and Life Sciences, LCRC, Diepenbeek (BS, IC, KN),The Department of Anaesthesiology, University Hospitals Leuven, Leuven (NM, MVdeV), The Department of Orthopaedic Surgery, Jessa Hospital, Hasselt (CV), KULeuven, Department of Cardiovascular Sciences, Leuven (KN, MVdeV), The Department of Pharmacy, Jessa Hospital, Hasselt, Belgium (EdeT, MD).

Björn Stessel et al. Eur J Anaesthesiol. 2025.

. 2025 Nov 19.

doi: 10.1097/EJA.0000000000002318. Online ahead of print.

¹ From the Department of Anaesthesiology and Pain Medicine, Jessa Hospital, Hasselt (BS, NM, IC, JV, SE, KN, AN, JD), UHasselt, Faculty of Medicine and Life Sciences, LCRC, Diepenbeek (BS, IC, KN),The Department of Anaesthesiology, University Hospitals Leuven, Leuven (NM, MVdeV), The Department of Orthopaedic Surgery, Jessa Hospital, Hasselt (CV), KULeuven, Department of Cardiovascular Sciences, Leuven (KN, MVdeV), The Department of Pharmacy, Jessa Hospital, Hasselt, Belgium (EdeT, MD).

No abstract available

References

1. Stessel B, Lambrechts M, Evers S, et al. Additive or synergistic analgesic effect of metamizole on standard pain treatment at home after arthroscopic shoulder surgery: a randomised controlled superiority trial. Eur J Anaesthesiol 2023; 40:171–178.
1. BCFI. Gecommentarieerd geneesmiddelen repertorium. www.bcfi.be2024.
1. Stessel B, Boon M, Pelckmans C, et al. Metamizole vs. ibuprofen at home after day case surgery: a double-blind randomised controlled noninferiority trial. Eur J Anaesthesiol 2019; 36:351–359.
1. Zajaczkowska R. Mechanisms of action of metamizole: a review of preclinical data. Pharmacol Rep 2020; 72:486–494.
1. Huber M, Andersohn F, Sarganas G, et al. Metamizole-induced agranulocytosis revisited: results from the prospective Berlin Case-Control Surveillance Study. Eur J Clin Pharmacol 2015; 71:219–227.