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. 1973 Sep;70(9):2624-8.
doi: 10.1073/pnas.70.9.2624.

Cell interactions between histoincompatible T and B lymphocytes. The H-2 gene complex determines successful physiologic lymphocyte interactions

D H Katz, T Hamaoka, M E Dorf, B Benacerraf

Cell interactions between histoincompatible T and B lymphocytes. The H-2 gene complex determines successful physiologic lymphocyte interactions

D H Katz et al. Proc Natl Acad Sci U S A. 1973 Sep.

Abstract

We used congenic-resistant mouse strains to answer questions concerning the respective roles of genes coding for major histocompatibility and background genotypes in T (thymus-derived)-B (bone marrow-derived) lymphocyte cooperative responses to hapten-protein conjugates. These studies demonstrate conclusively that the gene or genes present in the H-2 complex control the capacity of antigen-specific T and B cells to effectively interact. These findings led us to postulate that there exists on the B-lymphocyte surface an "acceptor" molecule for the active T-cell product or for the T cell itself.

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References

    1. J Exp Med. 1970 Feb;131(2):275-86 - PubMed
    1. Transplant Rev. 1972;12:141-79 - PubMed
    1. Transplant Rev. 1969;1:92-113 - PubMed
    1. J Exp Med. 1970 Aug 1;132(2):261-82 - PubMed
    1. J Exp Med. 1972 Sep 1;136(3):455-65 - PubMed

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