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. 1973 Nov 1;138(5):1184-93.
doi: 10.1084/jem.138.5.1184.

Homogenous rabbit 7S anti-IgG with antibody specificity for peptidoglycan

V A Bokisch, J W Chiao, D Bernstein, R M Krause

Homogenous rabbit 7S anti-IgG with antibody specificity for peptidoglycan

V A Bokisch et al. J Exp Med. .

Abstract

The relationship between 7S anti-IgG and antibodies to streptococcal cell wall peptidoglycan was examined for four streptococcal Group C antisera. Homogeneous 7S anti-IgG components in these sera were isolated by means of an IgG immunoadsorbent column. For two of the four antisera, the anti-peptidoglycan activity of the 7S anti-IgG had specificity for the pentapeptide, L-Ala-D-Glu-gamma-L-Lys-D-Ala-D-Ala, the antigenic determinant of peptidoglycan, as well as for the Fc of IgG. Detailed studies on the 7S anti-IgG from one of the antisera revealed that the pentapeptide inhibited the coprecipitation reaction of 7S anti-IgG R3387 with antigen-antibody complexes and the precipitin reaction between 7S anti-IgG R3387 and its anti-idiotype serum.

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