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. 1973 Nov 1;138(5):1276-81.
doi: 10.1084/jem.138.5.1276.

Overlap stimulation of primary and secondary B cells by cross-reacting determinants

N R Klinman, J L Press, G P Segal

Overlap stimulation of primary and secondary B cells by cross-reacting determinants

N R Klinman et al. J Exp Med. .

Abstract

Experiments were carried out to test the validity of the hypothesis that postulated differences in the nature of the antigen receptors of primary and secondary B cells should be reflected in a greater specificity in primary B-cell stimulation (2). Enumeration of clonal precursors stimulated by either DNP-Hy, TNP-Hy, or a mixture of both antigens confirmed this hypothesis. Since the sum of primary B cells stimulated by DNP-Hy and TNP-Hy is approximately equal to the number stimulated by a mixture of both, overlap stimulation of primary B cells by these antigens could be considered negligible. In contrast, the stimulation of B cells from mice previously immunized with DNP-Hy showed extensive overlap of stimulation by DNP-Hy and TNP-Hy. Thus secondary B cells appear less fastidious in their affinity requirements for stimulation than primary B cells.

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