Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 1973 Sep;12(3):458-63.
doi: 10.1128/JVI.12.3.458-463.1973.

Studies on the nucleic acid sequences of Kirsten sarcoma virus: a model for formation of a mammalian RNA-containing sarcoma virus

E M Scolnick, E Rands, D Williams, W P Parks
Comparative Study

Studies on the nucleic acid sequences of Kirsten sarcoma virus: a model for formation of a mammalian RNA-containing sarcoma virus

E M Scolnick et al. J Virol. 1973 Sep.

Abstract

The genetic information contained in the Kirsten and Moloney strains of mammalian RNA-containing sarcoma viruses has been analyzed by RNA . (3)H-DNA hybridization. Kirsten sarcoma virus has been found to possess two distinct sets of nucleic acid sequences. One set of sequences is contained in murine type C helper virus, and the other set is contained in rat type C helper virus. Moloney sarcoma virus contains sequences of murine type C helper virus but not of rat type C helper virus. The results indicate that Kirsten sarcoma virus arose through a process of recombination between Kirsten murine leukemia virus and nucleic acid sequences found in rat cells. A model is suggested for the formation of transforming type C viruses involving the transduction of oncogenic information.

PubMed Disclaimer

References

    1. Natl Cancer Inst Monogr. 1966 Sep;22:139-42 - PubMed
    1. Proc Natl Acad Sci U S A. 1966 Oct;56(4):1164-9 - PubMed
    1. Virology. 1969 Dec;39(4):930-1 - PubMed
    1. Proc Natl Acad Sci U S A. 1969 Nov;64(3):1087-94 - PubMed
    1. Nature. 1970 Sep 5;227(5262):1021-3 - PubMed

Publication types

MeSH terms

LinkOut - more resources