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. 1973 Dec;116(3):1336-42.
doi: 10.1128/jb.116.3.1336-1342.1973.

Temperature-sensitive nonsense mutations in essential genes of Escherichia coli

D Beckman, S Cooper

Temperature-sensitive nonsense mutations in essential genes of Escherichia coli

D Beckman et al. J Bacteriol. 1973 Dec.

Abstract

Cells containing nonsense mutations in essential genes have been isolated in a strain of Escherichia coli that carried the su4(ts) gene which specifies a temperature-sensitive tyrosine transfer ribonucleic acid. Such cells are unable to form colonies at temperatures which inactivate this suppressor transfer ribonucleic acid. A screening procedure for the identification of mutants that carry temperature-sensitive nonsense mutations in essential genes is described, and certain properties of two such mutants are reported.

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