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. 1973 Dec 1;138(6):1289-304.
doi: 10.1084/jem.138.6.1289.

A mouse B-cell alloantigen determined by gene(s) linked to the major histocompatibility complex

D H Sachs, J L Cone

A mouse B-cell alloantigen determined by gene(s) linked to the major histocompatibility complex

D H Sachs et al. J Exp Med. .

Abstract

Antibodies cytotoxic for only a subpopulation of C57Bl/10 lymph node and spleen cells were detected when rat antiserum against B10.D2 was exhaustively absorbed with B10.A lymphocytes. Antibodies of similar specificity were also detected in B10.A anti-B10.D2 and in B10.A anti-C57Bl/10 alloantisera. Reactions with recombinant strains of mice indicate that the cell-surface antigen(s) responsible for this specificity is determined by gene(s) in or to the left of the Ir-1 region of the major histocompatibility complex. A variety of criteria implicate B cells as the subpopulation of lymphocytes bearing this antigen. In view of these data and the recent report by others of a T-cell alloantigen determined by gene(s) in the major histocompatibility complex, it seems possible that there may be a variety of H-2-linked alloantigens expressed preferentially on subclasses of lymphocytes.

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