Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2025 Oct 29;10(11):722.
doi: 10.3390/biomimetics10110722.

Comparative Analysis of the Use of Osteoplastic Materials in Socket Augmentation: A Systematic Review

Affiliations
Review

Comparative Analysis of the Use of Osteoplastic Materials in Socket Augmentation: A Systematic Review

Diana Sologova et al. Biomimetics (Basel). .

Abstract

Background: Tooth extraction is often accompanied by bone tissue loss. This systematic review aims to compare osteoplastic materials for socket preservation.

Methods: This systematic review was carried out with the PRISMA statement. To identify relevant studies, a thorough literature search was executed in several databases, such as Medline, PubMed, Scopus, and the Cochrane Central Register of Controlled Trials. The inclusion criteria were restricted to randomized controlled trials, and their methodological quality was evaluated with the Cochrane Risk of Bias tool (ROB 2).

Results: Based on the predefined inclusion and exclusion criteria, nine randomized clinical trials published before 2024 were selected for analysis, all of them investigating the application of osteoplastic materials. Six studies performed xenogenic bone augmentation; one of them compared alloplastic and xenogenic materials; two studies described synthetic osteoplastic materials; and one described autogenic bone material.

Conclusion: Socket augmentation with osteoplastic materials demonstrates effectiveness in preserving alveolar ridge dimensions and creating favorable conditions for further implant placement, though differences in clinical performance highlight the need for careful material selection.

Keywords: alveolar bone loss; augmentation; biocompatibility; biomaterials; bone regeneration; bone remodeling; bone repair; bone resorption; bone substitute; guided bone regeneration; socket preservation; systematic review; tooth socket.

PubMed Disclaimer

Conflict of interest statement

The authors declare that there are no conflicts of interest.

Figures

Figure 1
Figure 1
Flow diagram describing the selection process according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) recommendations [27].

References

    1. Madi M., Almindil I., Alrassasi M., Alramadan D., Zakaria O., Alagl A.S. Cone-Beam Computed Tomography and Histological Findings for Socket Preservation Techniques Using Different Grafting Materials: A Systematic Review. J. Funct. Biomater. 2023;14:282. doi: 10.3390/jfb14050282. - DOI - PMC - PubMed
    1. Stumbras A., Kuliesius P., Januzis G., Juodzbalys G. Alveolar Ridge Preservation after Tooth Extraction Using Different Bone Graft Materials and Autologous Platelet Concentrates: A Systematic Review. J. Oral Maxillofac. Res. 2019;10:e2. doi: 10.5037/jomr.2019.10102. - DOI - PMC - PubMed
    1. Alavi S.A., Imanian M., Alkaabi S., Al-Sabri G., Forouzanfar T., Helder M. A Systematic Review and Meta-Analysis on the Use of Regenerative Graft Materials for Socket Preservation in Randomized Clinical Trials. Oral Surg. Oral Med. Oral Pathol. Oral Radiol. 2024;138:702–718. doi: 10.1016/j.oooo.2024.07.003. - DOI - PubMed
    1. de Carvalho Formiga M., Dayube U.R.C., Chiapetti C.K., de Rossi Figueiredo D., Shibli J.A. Socket Preservation Using a (Dense) PTFE Barrier with or without Xenograft Material: A Randomized Clinical Trial. Materials. 2019;12:2902. doi: 10.3390/ma12182902. - DOI - PMC - PubMed
    1. Chappuis V., Engel O., Reyes M., Shahim K., Nolte L.-P., Buser D. Ridge Alterations Post-Extraction in the Esthetic Zone: A 3D Analysis with CBCT. J. Dent. Res. 2013;92:195S–201S. doi: 10.1177/0022034513506713. - DOI - PMC - PubMed

LinkOut - more resources