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. 2025 Nov 6;14(11):1337.
doi: 10.3390/antiox14111337.

New Insights into Potential Anti-Aging and Fatigue Effects of a Dietary Supplement from the Resveratrol Beverage in Aged SAMP8 Mice

Yu-Chien Chen  1 , Ming-Yu Chou  2 , Po-Hsien Li  1 , Ying-Shen Lin  3 , Mei-Due Yang  4 , Ching-Hsin Chi  2 , Ping-Hsiu Huang  5 , Yun-Jhen Wei  1 , Ming-Fu Wang  1   2 , Chun-Yen Kuo  3
Affiliations

New Insights into Potential Anti-Aging and Fatigue Effects of a Dietary Supplement from the Resveratrol Beverage in Aged SAMP8 Mice

Yu-Chien Chen et al. Antioxidants (Basel). .

Abstract

This study investigated the anti-fatigue and anti-aging benefits of continuous intake of resveratrol (RES)-rich beverages. Locomotion and forelimb grip strength performance were significantly improved in medium- and high-dose RES groups. In terms of aging indices, the scores for the medium- and high-dose groups were significantly lower than those of the control group. In the PAT and active shuttle avoidance tests, the three RES groups performed better than the control group. A significant increase in SOD and catalase activity in the liver and a reduction in TBARS and 8-OHdG levels in the brain were observed in the medium- and high-dose groups. Thus, supplementation with RES-rich beverages for 13 weeks significantly improved fatigue, locomotor performance, learning and memory abilities, and liver antioxidant activity and reduced brain peroxide levels in SAMP8 mice.

Keywords: active shuttle avoidance tests; glycogen; passive avoidance task; resveratrol.

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Conflict of interest statement

The authors declare that they have no competing financial interests or personal relationships that could have influenced the work reported in this paper. The funding sponsors had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results.

Figures

Figure 1
Figure 1
Schedule of animal experiments. Random subgroup adaptation for 7 days, followed by treatment of mice with RES-rich beverages or water for 13 consecutive weeks.
Figure 2
Figure 2
Equipment used in the trial process: (A) Treadmill and (B) Grip strength meter.
Figure 3
Figure 3
Effects of RES-rich beverage oral administration to SAMP8 mice for 9–12 weeks on forelimb grip strength, passive avoidance task (PAT), and active shuttle avoidance. Values were expressed as mean ± SEM and analyzed by one-way ANOVA. Groups with different letters indicate significant differences (p < 0.05).
Figure 4
Figure 4
Effects of RES-rich beverage administration to SAMP8 mice for 0, 4, 8, and 13 weeks on locomotor ability assessment. Values were expressed as mean ± SEM and analyzed by one-way ANOVA. Groups with different letters indicate significant differences (p < 0.05).
Figure 5
Figure 5
Blood lactate levels, liver glucose levels, and bioactive indexes of aging in the brain and liver tissues for each group of SAMP8 mice after exercise. Different lowercase letters represent significant differences (p < 0.05).
See this image and copyright information in PMC

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