Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2025 Nov 1;16(11):1300.
doi: 10.3390/genes16111300.

Effects of Exercise Addiction and the COL1A1 Gene rs1800012 Polymorphism on Injury Susceptibility in Elite Female Volleyball Players

Muhammed Mustafa Piri  1 , Mesut Cerit  1 , Murat Anılır  2 , Tolga Polat  3 , Aynur Ayşe Karaduman  4 , Attila Szabo  5 , Tiffany Georges Abi Antoun  6   7 , George John  7 , Ekaterina A Semenova  8   9 , Andrey K Larin  8 , Nikolay A Kulemin  8 , Edward V Generozov  8 , Ildus I Ahmetov  8   10   11
Affiliations

Effects of Exercise Addiction and the COL1A1 Gene rs1800012 Polymorphism on Injury Susceptibility in Elite Female Volleyball Players

Muhammed Mustafa Piri et al. Genes (Basel). .

Abstract

Objectives: The objective of this study was to separately examine the effects of exercise addiction and the Collagen Type I Alpha 1 Chain (COL1A1) gene rs1800012 G/T polymorphism on injury susceptibility in elite female volleyball players, and to test the hypothesis that the T allele, previously identified as a risk allele, is underrepresented in volleyball players compared to the general population.

Methods: The study included 50 professional Turkish female volleyball players with documented injury data, along with 557 Turkish controls, 53 professional Russian volleyball players, and 810 Russian controls. The Turkish participants were enrolled in a case-control study, an injury study, and an exercise addiction study, whereas the Russian participants were enrolled solely in a case-control study.

Results: Injured players had significantly higher scores in the Delay of Individual Social Needs and Conflict subscale of the Exercise Addiction Scale compared to their uninjured counterparts (p = 0.036). The random-effects meta-analysis revealed a significantly lower frequency of the COL1A1 T allele in volleyball players compared to controls (pooled OR = 0.63, 95% CI: 0.41-0.96, p = 0.031). Athletes who had not undergone surgery had a significantly higher frequency of the G allele compared to controls (89.2% vs. 78.7%, p = 0.037; OR = 2.23, 95% CI: 1.1-4.7). Among injured athletes, those carrying the GT genotype were significantly more likely to experience prolonged recovery (≥3 months) (57.1%) compared to those with the GG genotype (28.0%, p = 0.017).

Conclusions: Exercise addiction and the COL1A1 rs1800012 T allele were associated with a higher incidence of injury in female volleyball players. The T allele was also associated with a longer recovery time following injury.

Keywords: COL1A1; exercise addiction; polymorphism; sport injuries; volleyball.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Meta-analysis of association studies examining the COL1A1 gene and volleyball player status. The under-representation of the COL1A1 T allele is evident in the volleyball players. The purple squares indicate the proportion of the T allele among volleyball players in each individual study, while the black diamond represents the pooled proportion of the T allele across all volleyball players, along with its 95% confidence interval (CI).
Figure 2
Figure 2
COL1A1 rs1800012 G allele frequency differences among Turkish athletes who had not undergone surgery (n = 37), athletes who had undergone surgery (n = 13), and controls (n = 557). * p = 0.037 (Fisher’s exact test), indicating statistical significance.
See this image and copyright information in PMC

References

    1. Griffin L.Y., Albohm M.J., Arendt E.A., Bahr R., Beynnon B.D., Demaio M., Dick R.W., Engebretsen L., Garrett W.E., Jr., Hannafin J.A., et al. Understanding and Preventing Noncontact Anterior Cruciate Ligament Injuries: A Review of the Hunt Valley II Meeting, January 2005. Am. J. Sports Med. 2006;34:1512–1532. doi: 10.1177/0363546506286866. - DOI - PubMed
    1. Emery C.A., Pasanen K. Current Trends in Sport Injury Prevention. Best Pract. Res. Clin. Rheumatol. 2019;33:3–15. doi: 10.1016/j.berh.2019.02.009. - DOI - PubMed
    1. Lohmander L.S., Ostenberg A., Englund M., Roos H. High Prevalence of Knee Osteoarthritis, Pain, and Functional Limitations in Female Soccer Players Twelve Years after Anterior Cruciate Ligament Injury. Arthritis Rheum. 2004;50:3145–3152. doi: 10.1002/art.20589. - DOI - PubMed
    1. Podlog L., Eklund R.C. Return to Sport after Serious Injury: A Retrospective Examination of Motivation and Psychological Outcomes. J. Sport Rehabil. 2005;14:20–34. doi: 10.1123/jsr.14.1.20. - DOI
    1. Appaneal R.N., Levine B.R., Perna F.M., Roh J.L. Measuring Postinjury Depression among Male and Female Competitive Athletes. J. Sport Exerc. Psychol. 2009;31:60–76. doi: 10.1123/jsep.31.1.60. - DOI - PubMed