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Review
. 2025 Dec:75:152887.
doi: 10.1016/j.semarthrit.2025.152887. Epub 2025 Nov 22.

The state of the Osteoarthritis Initiative (OAI): Entering a new era

Jeffrey B Driban  1 , Julieann C Patarini  2 , Shao-Hsien Liu  3 , Timothy E McAlindon  4 , Kate L Lapane  5 , Stephenie C Lemon  6 , Adrian H Zai  7 , Michael C Nevitt  8 , Marc C Hochberg  9 , Jane A Cauley  10 , Charles B Eaton  11 , Susan Rubin  12 , Erika Schneider  13 , Grace H Lo  14
Affiliations
Review

The state of the Osteoarthritis Initiative (OAI): Entering a new era

Jeffrey B Driban et al. Semin Arthritis Rheum. 2025 Dec.
No abstract available

Keywords: Biobanking; Biomarkers; Cohort studies; Knee osteoarthritis; Magnetic resonance imaging; Radiography.

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Conflict of interest statement

Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Jeffrey Driban reports financial support was provided by National Institutes of Health. Timothy McAlindon reports a relationship with Sanofi that includes: consulting or advisory. Timothy McAlindon reports a relationship with Kolon TissueGene that includes: consulting or advisory. Timothy McAlindon reports a relationship with Medidata that includes: consulting or advisory. Timothy McAlindon reports a relationship with Organogenesis Inc that includes: consulting or advisory. Timothy McAlindon reports a relationship with Ambulomics that includes: equity or stocks. Timothy McAlindon reports a relationship with Arthrometrics that includes: equity or stocks. Jeffrey Driban and Timothy McAlindon has patent Objective Assessment of Joint Damage; Patent No 12,307,671; 2025. issued to Tufts Medical Center, Inc and Trustees of Boston University. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Figure 1.
Figure 1.. Timing of Osteoarthritis Initiative Visits.
Orange = The originally funded visits (up to 48 months). Green = The initial extension of follow-up visits (60 to 96 months). Blue = Follow-up visits funded by various NIH grants. * = Participants contacted by telephone only. ** = only a subset of participants invited.
Figure 2.
Figure 2.
Publications Listed in PubMed that Referenced the Osteoarthritis Initiative (OAI) Each Year
Figure 3.
Figure 3.
World map depicting the number of published documents (e.g., peer-reviewed papers, conference papers) per country related to the Osteoarthritis Initiative
Figure 4.
Figure 4.
Network map of authors with at least 15 OAI-related manuscripts
See this image and copyright information in PMC

References

    1. Felson DT, Niu J, Guermazi A et al. Defining radiographic incidence and progression of knee osteoarthritis: suggested modifications of the Kellgren and Lawrence scale. Ann Rheum Dis 2011;70:1884–6. 10.1136/ard.2011.155119. - DOI - PMC - PubMed
    1. Felson DT, Nevitt MC, Yang M et al. A new approach yields high rates of radiographic progression in knee osteoarthritis. J Rheumatol 2008;35:2047–54. - PMC - PubMed
    1. Duryea J, Li J, Peterfy CG et al. Trainable rule-based algorithm for the measurement of joint space width in digital radiographic images of the knee. Med Phys 2000;27:580–91. 10.1118/1.598897. - DOI - PubMed
    1. Neumann G, Hunter D, Nevitt M et al. Location specific radiographic joint space width for osteoarthritis progression. Osteoarthritis Cartilage 2009;17:761–5. 10.1016/j.joca.2008.11.001. - DOI - PMC - PubMed
    1. Joseph GB, McCulloch CE, Nevitt MC et al. Effects of Weight Change on Knee and Hip Radiographic Measurements and Pain Over Four Years: Data From the Osteoarthritis Initiative. Arthritis Care Res (Hoboken) 2023;75:860–8. 10.1002/acr.24875. - DOI - PMC - PubMed

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