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. 2025 Dec;26(12):e624.
doi: 10.1016/S1470-2045(25)00655-2.

Misclassification of p16-positive, HPV-negative patients biases de-escalation trials - Authors' reply

David M Routman  1 , James S Lewis  2 , Daniel J Ma  3
Affiliations

Misclassification of p16-positive, HPV-negative patients biases de-escalation trials - Authors' reply

David M Routman et al. Lancet Oncol. 2025 Dec.
No abstract available

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Conflict of interest statement

DMR reports funding from the Paul Calabresi Program in Clinical/Translational Research (K12CA090628), licensing with EXACT sciences, and presentations with Adela Biosciences, none of which were involved in the trial. DJM reports intellectual property with EXACT Sciences, In Situ Biologics, and CurrentHealth, none of which were involved in the trial. JSL declares no competing interests.

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