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Review
. 2025 Nov 27.
doi: 10.1038/s41585-025-01111-w. Online ahead of print.

Micro-ultrasound for prostate cancer

Melis Guer  1   2 , Wayne G Brisbane  3 , Hannes Cash  4 , Sangeet Ghai  5 , Laurence Klotz  6 , Paul F R Wilson  7 , Adam Kinnaird  8   9
Affiliations
Review

Micro-ultrasound for prostate cancer

Melis Guer et al. Nat Rev Urol. .

Abstract

The diagnostic workflow for prostate cancer detection has evolved substantially with advances in imaging technologies and biopsy techniques. Currently, MRI is the standard modality for prostate imaging in cancer detection. However, the rising incidence of prostate cancer and the limited accessibility and high cost of MRI created a growing need for more cost- and time-effective alternative imaging modalities. Micro-ultrasound (microUS), which enables prostatic ductal anatomy to be imaged with a 70-micron resolution, provides an alternative. Level 1 evidence currently shows the non-inferiority of microUS in detecting Grade Group ≥2 prostate cancer in biopsy-naive men compared with MRI. Clinical trials are ongoing to investigate microUS in various other indications. Inter-reader variability needs to be optimized, possibly through the incorporation of artificial intelligence (AI) assistance.

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Conflict of interest statement

Competing interests: The authors declare no competing interests.

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