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. 1974 Apr 1;139(4):925-42.
doi: 10.1084/jem.139.4.925.

Common cell surface antigen associated with mammalian C-type RNA viruses. Cell membrane-bound gs antigen

T Yoshiki, R C Mellors, W D Hardy Jr, E Fleissner

Common cell surface antigen associated with mammalian C-type RNA viruses. Cell membrane-bound gs antigen

T Yoshiki et al. J Exp Med. .

Abstract

The indirect membrane immunofluorescence test and the absorption analysis of rabbit anti-FeLV, rabbit anti-FeLVp 30, and rabbit anti-MuLVp 30 antisera yielded the following conclusions. An antigen shared by mammalian (murine and feline) C-type RNA leukemia and sarcoma viruses was detected on the surface of cells infected or transformed by C-type viruses. The antigen was characterized as membrane-bound gs antigen bearing two determinants, membrane-bound gs-1, intraspecies-specific antigenic determinant, and membrane-bound gs-3, interspecies-specific antigenic determinant. Membrane-bound gs antigen was located on the cell surface, frequently near the site of virus budding but not on the envelope of murine C-type RNA virus.

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