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Published Erratum
. 2025 Nov 29;44(1):315.
doi: 10.1186/s13046-025-03597-z.

Correction: Deciphering the tumor immune microenvironment: single-cell and spatial transcriptomic insights into cervical cancer fibroblasts

Zhiheng Lin #  1 , Youwei Zhou #  2 , Zhenran Liu #  2 , Wenyang Nie #  3 , Hengjie Cao  1 , Shengnan Li  1 , Xuanling Li  1 , Lijun Zhu  1 , Guangyao Lin  1 , Yanyu Ding  4   5 , Yi Jiang #  6 , Zuxi Gu #  7 , Lianwei Xu #  8 , Zhijie Zhao #  9 , Huabao Cai #  10   11
Affiliations
Published Erratum

Correction: Deciphering the tumor immune microenvironment: single-cell and spatial transcriptomic insights into cervical cancer fibroblasts

Zhiheng Lin et al. J Exp Clin Cancer Res. .
No abstract available

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Figures

Fig. 12
Fig. 12
C0 MYH11 + CAF promotes tumor cell proliferation, migration, and inhibits apoptosis via soluble SDC1. A Experimental procedure for co-culture of C0 MYH11 + CAF with high- and low-invasive cervical cancer cells. Supernatants were collected and used to treat tumor cells. B shRNA-mediated silencing of SDC1 in C0 MYH11 + CAF resulted in reduced SDC1 expression. Western blot showing SDC1 levels in control and silenced groups. C Recombinant SDC1 treatment (200 ng/mL) promoted tumor cell proliferation, whereas 500 ng/mL inhibited proliferation. D Spheroid formation assay showing enhanced stemness and malignancy in tumor cells co-cultured with C0 MYH11 + CAF or treated with its supernatant. E Migration assay indicating increased migratory ability of tumor cells exposed to C0 MYH11 + CAF or its culture supernatant. F-G qRT-PCR analysis of apoptosis-related gene expression showing upregulation of anti-apoptotic and downregulation of pro-apoptotic genes in tumor cells treated with C0 MYH11 + CAF supernatant, suggesting reduced apoptosis
Fig. 12
Fig. 12
C0 MYH11 + CAF promotes tumor cell proliferation, migration, and inhibits apoptosis via soluble SDC1. A Experimental procedure for co-culture of C0 MYH11 + CAF with high- and low-invasive cervical cancer cells. Supernatants were collected and used to treat tumor cells. B shRNA-mediated silencing of SDC1 in C0 MYH11 + CAF resulted in reduced SDC1 expression. Western blot showing SDC1 levels in control and silenced groups. C Recombinant SDC1 treatment (200 ng/mL) promoted tumor cell proliferation, whereas 500 ng/mL inhibited proliferation. D Spheroid formation assay showing enhanced stemness and malignancy in tumor cells co-cultured with C0 MYH11 + CAF or treated with its supernatant. E Migration assay indicating increased migratory ability of tumor cells exposed to C0 MYH11 + CAF or its culture supernatant. F-G qRT-PCR analysis of apoptosis-related gene expression showing upregulation of anti-apoptotic and downregulation of pro-apoptotic genes in tumor cells treated with C0 MYH11 + CAF supernatant, suggesting reduced apoptosis
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Erratum for

References

    1. Lin Z, Zhou Y, Liu Z, et al. Deciphering the tumor immune microenvironment: single-cell and spatial transcriptomic insights into cervical cancer fibroblasts. J Exp Clin Cancer Res. 2025;44:194. 10.1186/s13046-025-03432-5. - DOI - PMC - PubMed

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