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. 1978 Jan 13;199(4325):199-200.
doi: 10.1126/science.413192.

Environmental hydrocarbons produce degeneration in cat hypothalamus and optic tract

H H Schaumburg, P S Spencer

Environmental hydrocarbons produce degeneration in cat hypothalamus and optic tract

H H Schaumburg et al. Science. .

Abstract

2,5-Hexanedione, the principal neurotoxic metabolite of the industrial solvents n-hexane and methyl n-butyl ketone causes axonal degeneration in the mammillary body and visual nuclei of cats. Prolonged, low-level exposure to hydrocarbons in the environment may cause premature deterioration in areas of the human brain vital for perception and behavior.

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