When LOFTy Ideals Meet Clinical Trial Reality

Sushmita Pamidi^{1

2}, Ryan Zarychanski³, Robert L Owens⁴

Affiliations

¹ Respiratory Epidemiology and Clinical Research Unit, Department of Medicine, McGill University, Montreal, Quebec, Canada.
² Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada.
³ Department of Internal Medicine, University of Manitoba, Winnipeg, Manitoba, Canada; and.
⁴ Division of Pulmonary, Critical Care and Sleep Medicine, University of California, San Diego, La Jolla, California.

Editorial

Sushmita Pamidi et al. Ann Am Thorac Soc. 2025 Dec.

. 2025 Dec;22(12):1833-1834.

doi: 10.1513/AnnalsATS.202510-1095ED.

Sushmita Pamidi^{1

2}, Ryan Zarychanski³, Robert L Owens⁴

¹ Respiratory Epidemiology and Clinical Research Unit, Department of Medicine, McGill University, Montreal, Quebec, Canada.
² Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada.
³ Department of Internal Medicine, University of Manitoba, Winnipeg, Manitoba, Canada; and.
⁴ Division of Pulmonary, Critical Care and Sleep Medicine, University of California, San Diego, La Jolla, California.

No abstract available

Figures

Nocturnal Oxygen Therapy for Central Sleep Apnea in Patients with Heart Failure: A Multisite, Double-Blind, Sham-controlled Randomized Clinical Trial (LOFT-HF).
Redline S, Li D, Javaheri S, Patel SR, Parthasarathy S, Fang JC, Brown LK, Dunlap M, Badr MS, Shah N, Chi L, Majid R, Teodorescu M, Stewart G, Hsich E, Polonsky T, Vader J, Johnson MR, Auckley D, Yaggi HK, Kao A, Azarbarzin A, Alex R, Rueschman M, Wolfe L, Gottlieb DJ, Sands SA, Zee PC, Mehra R, Mokhlesi B, Khayat R, Lewis EF, Abraham WT, Wang R. Redline S, et al. Ann Am Thorac Soc. 2025 Dec;22(12):1951-1960. doi: 10.1513/AnnalsATS.202504-409OC. Ann Am Thorac Soc. 2025. PMID: 40929650 Free PMC article. Clinical Trial.

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