Editorial Expression of Concern: Cytokinesis failure generating tetraploids promotes tumorigenesis in p53-null cells

Affiliations

¹ Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA.
² Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA.
³ Department of Biomedical Sciences, Tufts University Veterinary School, North Grafton, Massachusetts, USA.
⁴ Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA. david_pellman@dfci.harvard.edu.
⁵ Pediatric Hematology/Oncology, Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA. david_pellman@dfci.harvard.edu.

^# Contributed equally.

Takeshi Fujiwara et al. Nature. 2025 Dec.

. 2025 Dec;648(8094):E19.

doi: 10.1038/s41586-025-09942-8.

¹ Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA.
² Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA.
³ Department of Biomedical Sciences, Tufts University Veterinary School, North Grafton, Massachusetts, USA.
⁴ Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA. david_pellman@dfci.harvard.edu.
⁵ Pediatric Hematology/Oncology, Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA. david_pellman@dfci.harvard.edu.

^# Contributed equally.

No abstract available

Expression of concern for

Cytokinesis failure generating tetraploids promotes tumorigenesis in p53-null cells.
Fujiwara T, Bandi M, Nitta M, Ivanova EV, Bronson RT, Pellman D. Fujiwara T, et al. Nature. 2005 Oct 13;437(7061):1043-7. doi: 10.1038/nature04217. Nature. 2005. PMID: 16222300