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. 1974 May 1;139(5):1077-83.
doi: 10.1084/jem.139.5.1077.

Immunohistochemical demonstration of IgG in Reed-Sternberg and other cells in Hodgkin's disease

A J Garvin, S S Spicer, R T Parmley, A M Munster

Immunohistochemical demonstration of IgG in Reed-Sternberg and other cells in Hodgkin's disease

A J Garvin et al. J Exp Med. .

Abstract

Spleens and lymph nodes fixed lightly for optimal immunocytochemistry or processed routinely for surgical diagnosis disclosed strong selective immunostaining for IgG in numerous immunocytes in tumor-free areas. Areas involved by Hodgkin's disease revealed, in addition, strong immunostaining for IgG but not IgM in Reed-Sternberg cells and faint to strong staining in Hodgkin cells as well. Ultrastructurally the Reed-Sternberg and Hodgkin cells displayed abundant polyribosomes and sparse granular reticulum and appeared to form unexportable IgG on unbound ribosomes.

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