Structurally diverse sesquiterpenoid glycosides with anti-inflammatory activity from Cissampelopsis spelaeicola

Si-Hang Lin¹, Ning Diao¹, Yan Wang², Dong Liang³

Affiliations

¹ Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education of China), Guangxi Key Laboratory of Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin, 541004, China; School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou, 510006, China.
² Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education of China), Guangxi Key Laboratory of Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin, 541004, China; H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan. Electronic address: wy198565@163.com.
³ Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education of China), Guangxi Key Laboratory of Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin, 541004, China; School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou, 510006, China. Electronic address: liangdong@gdpu.edu.cn.

PMID: 41330447
DOI: 10.1016/j.phytochem.2025.114734

Structurally diverse sesquiterpenoid glycosides with anti-inflammatory activity from Cissampelopsis spelaeicola

Si-Hang Lin et al. Phytochemistry. 2025.

. 2025 Nov 30:243:114734.

doi: 10.1016/j.phytochem.2025.114734. Online ahead of print.

Authors

Si-Hang Lin¹, Ning Diao¹, Yan Wang², Dong Liang³

Affiliations

¹ Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education of China), Guangxi Key Laboratory of Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin, 541004, China; School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou, 510006, China.
² Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education of China), Guangxi Key Laboratory of Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin, 541004, China; H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan. Electronic address: wy198565@163.com.
³ Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education of China), Guangxi Key Laboratory of Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin, 541004, China; School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou, 510006, China. Electronic address: liangdong@gdpu.edu.cn.

PMID: 41330447
DOI: 10.1016/j.phytochem.2025.114734

Abstract

Sixteen previously undescribed sesquiterpenoid glycosides (1-16), bearing eudesmane-type (1-4) and cadinane-type skeletons (5-16), were obtained from the stems of Cissampelopsis spelaeicola. The structural elucidation and absolute configuration assignment of compounds 1-16 were accomplished through multiple spectroscopic analyses, computed ECD/NMR, and X-ray crystallography. Furthermore, anti-neuroinflammatory effects of all isolates were assessed by NO inhibition in LPS-stimulated BV-2 microglia. Compounds 12 and 14-16 exhibited potent NO inhibitory effects (IC₅₀ = 5.62-19.29 μM), outperforming the positive control L-NMMA (IC₅₀ = 21.20 ± 0.57 μM). Further evaluation revealed that compound 15 (IC₅₀ = 5.62 ± 0.37 μM) effectively attenuated LPS-stimulated overexpression of IL-1β, IL-6, iNOS, and TNF-α in BV-2 cells.

Keywords: Asteraceae; Cadinane-type; Cissampelopsis spelaeicola; Eudesmane-type; NO inhibition; Neuroinflammation; Sesquiterpenoid glycosides.

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Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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Structurally diverse sesquiterpenoid glycosides with anti-inflammatory activity from Cissampelopsis spelaeicola

Affiliations

Structurally diverse sesquiterpenoid glycosides with anti-inflammatory activity from Cissampelopsis spelaeicola

Authors

Affiliations

Abstract

Conflict of interest statement

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Full Text Sources