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. 2025 Dec 2;15(1):43009.
doi: 10.1038/s41598-025-17767-8.

Editorial Expression of Concern: Intranasal vaccination of hamsters with a Newcastle disease virus vector expressing the S1 subunit protects animals against SARS-CoV-2 disease

Manolo Fernández Díaz  1 , Katherine Calderón  2 , Aldo Rojas-Neyra  2 , Vikram N Vakharia  3 , Ricardo Choque-Guevara  2 , Angela Montalvan-Avalos  2 , Astrid Poma-Acevedo  2 , Dora Rios-Matos  2 , Andres Agurto-Arteaga  2 , Maria de Grecia Cauti-Mendoza  2 , Norma Perez-Martinez  2 , Gisela Isasi-Rivas  2 , Luis Tataje-Lavanda  2 , Yacory Sernaque-Aguilar  2 , Freddy Ygnacio  2 , Manuel Criollo-Orozco  2 , Edison Huaccachi-Gonzalez  2 , Elmer Delgado-Ccancce  2 , Doris Villanueva-Pérez  2 , Ricardo Montesinos-Millán  2 , Kristel Gutiérrez-Manchay  2 , Katherinne Pauyac-Antezana  2 , Ingrid Ramirez-Ortiz  2 , Stefany Quiñones-Garcia  2 , Yudith Cauna-Orocollo  2 , Katherine Vallejos-Sánchez  2 , Angela Rios-Angulo  2 , Dennis Núñez-Fernández  2 , Mario I Salguedo-Bohorquez  2 , Julio Ticona  2 , Manolo Fernández-Sánchez  2 , Eliana Icochea  2 , Luis A Guevara-Sarmiento  2 , Mirko Zimic  4 ; COVID-19 Working Group in Perú
Collaborators, Affiliations

Editorial Expression of Concern: Intranasal vaccination of hamsters with a Newcastle disease virus vector expressing the S1 subunit protects animals against SARS-CoV-2 disease

Manolo Fernández Díaz et al. Sci Rep. .
No abstract available

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Conflict of interest statement

MF is the CEO of FARVET. VV is an unpaid consultant to FARVET. MZ is a paid consultant to FARVET. All other authors are salaried employees of FARVET. The study was funded with FARVET’s own resources, and a partial funding from The National Council of Science and Technology from Peru (CONCYTEC- FONDECYT) was received for building the BSL3 facility to conduct the efficacy assays. The vaccine, which is the subject of this study, was developed by the FARVET scientific team. MF, KC and ARN are the inventors of this vaccine. The vaccine has been patented by FARVET. This vaccine is based on a NDV-construct previously developed by FARVET and patented in 2014. All other authors have nothing to declare.

Figures

Fig. 6
Fig. 6
Efficacy of live NDV vaccines against SARS-CoV-2 infection in hamsters. Golden Syrian hamster groups vaccinated with rLS1-S1-F, rLS1-HN-RBD, the mixture rLS1-S1-F/rLS1-HN-RBD, or non-vaccinated (positive control) were challenged 30 days after the boost with SARS-CoV-2, along with a mock group that was non-vaccinated nor challenged (negative control). (A) Viral isolation (% of animals that were positive for SARS-CoV-2) was done from the lung of each hamster group (n = 4) at days 2, 5, and 10 post-challenge.Two-way ANOVA and Tukey’s post hoc were performed.
See this image and copyright information in PMC

Expression of concern for

  • Intranasal vaccination of hamsters with a Newcastle disease virus vector expressing the S1 subunit protects animals against SARS-CoV-2 disease.
    Díaz MF, Calderón K, Rojas-Neyra A, Vakharia VN, Choque-Guevara R, Montalvan-Avalos A, Poma-Acevedo A, Rios-Matos D, Agurto-Arteaga A, Cauti-Mendoza MG, Perez-Martinez N, Isasi-Rivas G, Tataje-Lavanda L, Sernaque-Aguilar Y, Ygnacio F, Criollo-Orozco M, Huaccachi-Gonzalez E, Delgado-Ccancce E, Villanueva-Pérez D, Montesinos-Millán R, Gutiérrez-Manchay K, Pauyac-Antezana K, Ramirez-Ortiz I, Quiñones-Garcia S, Cauna-Orocollo Y, Vallejos-Sánchez K, Rios-Angulo A, Núñez-Fernández D, Salguedo-Bohorquez MI, Ticona J, Fernández-Sánchez M, Icochea E, Guevara-Sarmiento LA, Zimic M; COVID-19 Working Group in Perú. Díaz MF, et al. Sci Rep. 2022 Jun 20;12(1):10359. doi: 10.1038/s41598-022-13560-z. Sci Rep. 2022. PMID: 35725862 Free PMC article.

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