Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2025 Dec 2.
doi: 10.1038/s41440-025-02179-y. Online ahead of print.

Renin-angiotensin-aldosterone system inhibitors - why they won't help in COVID-19

Chia Siang Kow  1   2 , Syed Shahzad Hasan  1 , Kaeshaelya Thiruchelvam  3
Affiliations

Renin-angiotensin-aldosterone system inhibitors - why they won't help in COVID-19

Chia Siang Kow et al. Hypertens Res. .
No abstract available

Keywords: ACEI; ARB; COVID-19; RAAS.

PubMed Disclaimer

Conflict of interest statement

Compliance with ethical standards. Conflict of interest: The authors declare no competing interests.

References

    1. Matsuzawa Y, Tsujita K. Impact of SARS-CoV-2 variants on viral infectivity and the role of the renin-angiotensin-aldosterone system. Hypertens Res. 2025. https://doi.org/10.1038/s41440-025-02115-0 . Published online January 28 - DOI - PubMed
    1. Schaich CL, Chappell MC, Shotwell MS, et al. The Circulating Renin-Angiotensin System and Mortality among Patients Hospitalized for COVID-19: A Mechanistic Substudy of the ACTIV-4 Host Tissue Trials. Am J Physiol Lung Cell Mol Physiol. 2025. https://doi.org/10.1152/ajplung.00372.2024 . Published online January 30 - DOI - PubMed
    1. Sama IE, Ravera A, Santema BT, et al. Circulating plasma concentrations of angiotensin-converting enzyme 2 in men and women with heart failure and effects of renin-angiotensin-aldosterone inhibitors. Eur Heart J. 2020;41:1810–17. - DOI - PubMed - PMC
    1. Chirinos JA, Cohen JB, Zhao L, et al. Clinical and Proteomic Correlates of PlasmaACE2 (Angiotensin-Converting Enzyme 2) in Human Heart Failure [publishedcorrection appears in Hypertension. Hypertension. 2021;77:1526–36.
    1. Furuhashi M, Sakai A, Tanaka M, et al. Distinct Regulation of U-ACE2 and P-ACE2 (Urinary and Plasma Angiotensin-Converting Enzyme 2) in a Japanese General Population. Hypertension. 2021;78:1138–49. - DOI - PubMed

LinkOut - more resources