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. 2025 May 5;1(1):10.70962/jhi.20250001.
doi: 10.70962/jhi.20250001. Epub 2025 Feb 26.

Human immunity

Jean-Laurent Casanova  1   2   3   4   5
Affiliations

Human immunity

Jean-Laurent Casanova. J Hum Immun. .

Abstract

Due to the burden of infectious diseases, human life expectancy at birth remained about 20-25 years until the end of the 19th century, implying that host defense-which operates at the individual level, and only poorly at that-is barely sufficient at population level. Microbes preceded us by three billion years and evolve much more rapidly. Moreover, protective immunity has been selected at the evolutionary cost of allergy, autoinflammation, and autoimmunity. It is therefore no exaggeration to predict that almost all humans carry inborn errors of immunity, with insufficient or excessive responses to some environmental triggers, infectious or otherwise. Thanks to the remarkable power of its concepts and recent progress in its methods, genetics has finally made it possible to investigate the mechanisms of human immunity at the molecular and cellular levels. Human inborn errors provide countless opportunities to analyze immunity and its derailments in natural conditions, at an unprecedented scale, and are thus a unique asset from both biological and medical perspectives. Hence, the Journal of Human Immunity.

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Figures

Figure 1.
Figure 1.. This photo was taken in June 2023 in Paris.
Jean-Laurent Casanova (Editor of the Journal of Clinical Immunology) was hosting a reunion that included Vinny Bonagura (Editor of the Journal of Clinical Immunology), Sudhir Gupta (Founding Editor of the Journal of Clinical Immunology), Fabio Candotti (representing the European Society for Immunodeficiencies [ESID]), Elonora Gambineri (ESID), Stuart Tangye (Australasian Society of Clinical Immunology and Allergy [ASCIA]), Tomohiro Morio (Japanese Society for Immunodeficiency and Autoinflammatory Diseases, JSIAD), Satoshi Okada (JSIAD), Surjit Singh (Asia-Pacific Society for Immunodeficiencies [APSID]), Yu-Lung Lau (APSID), Davood Mansoori (Iranian Primary Immunodeficiency Network [IPIN]), Nima Rezaei (IPIN), Biman Saikia (Indian Society for Primary Immune Deficiency [ISPID]), Elisaveta Naumova (J Project), Jinqiao Sun (Chinese Society for Inborn Errors of Immunity [CSIEI]), Dusan Bogunovic (Henry Kunkel Society [HKS]), Isabelle Meyts (International Union of Immunological Societies [IUIS], committee for Inborn Errors of Immunity), Cecilia Poli (Latin American Society for Immunodeficiencies [LASID]), Aziz Bousfiha (Arab Society for Primary Immunodeficiencies [ARAPID]), Leila Jeddane (African Society for Immunodeficiencies [ASID]), and Elie Haddad (Clinical Immunology Society [CIS]). A representative of each of these 14 societies in the field of human inborn errors of immunity serves on the Board of Society Editors of the Journal of Human Immunity.
See this image and copyright information in PMC

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