ARNI Over ACEI Lacks Clinical Benefit in Patients With Chagas Cardiomyopathy

Robert L Gottlieb^{1

2

3

4}, Melina Giugni⁵, Ricardo M La Hoz⁶

Affiliations

¹ Baylor University Medical Center, Dallas, Texas.
² Baylor Scott & White The Heart Hospital, Dallas, Texas.
³ Texas A&M Health Science Center, Dallas.
⁴ Burnett School of Medicine at TCU, Fort Worth, Texas.
⁵ Heart Institute (InCor), Instituto do Coração, Hospital das Clínicas, HCFMUSP, Universidade de São Paulo, São Paulo, Brasil.
⁶ Division of Infectious Diseases & Geographic Medicine, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas.

Comment

Robert L Gottlieb et al. JAMA. 2026.

. 2026 Jan 6;335(1):30-32.

doi: 10.1001/jama.2025.23291.

Robert L Gottlieb^{1

2

3

4}, Melina Giugni⁵, Ricardo M La Hoz⁶

¹ Baylor University Medical Center, Dallas, Texas.
² Baylor Scott & White The Heart Hospital, Dallas, Texas.
³ Texas A&M Health Science Center, Dallas.
⁴ Burnett School of Medicine at TCU, Fort Worth, Texas.
⁵ Heart Institute (InCor), Instituto do Coração, Hospital das Clínicas, HCFMUSP, Universidade de São Paulo, São Paulo, Brasil.
⁶ Division of Infectious Diseases & Geographic Medicine, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas.

No abstract available

Comment on

Sacubitril/Valsartan vs Enalapril in Heart Failure Due to Chagas Disease: An Open-Label, Multicenter Randomized Clinical Trial.
Lopes RD, Bocchi EA, Echeverría LE, Demacq C, de Barros E Silva PGM, Barbosa LM, Damiani L, Sayyed S, Yoshida LAF, Furtado RHM, Morillo CA, Kevorkian R, Ramires F, Bahit MC, Magaña A, Chávez-Mendoza A, Miguel da Silva AH, Coelho da Silva A, Freitas AF Jr, Romano AA, Parneix A, Segura A, França CCB, Botta CE, de Barros E, Perna ER, Montenegro E, Quiroz Diaz FR, Feitosa-Filho GS, Severini GV, Molina I, Miranda JDSS, Sala J, Kerr Saraiva JF, Carbajales J, Maia LN, Santana Passos LC, Simões MV, Moreira MDCV, Nunes MCP, Hernandes ME, Hominal M, Zarandon RS, Leon de la Fuente R, Aras R, Bazan SGZ, Luiz da Silva T Jr, Madrini V, de Oliveira WA Jr, Saporito WF, Gimpelewicz C, McMurray JJV; Prevention and Reduction of Adverse Outcomes in Chagasic Heart Failure Trial Evaluation (PARACHUTE-HF) Investigators. Lopes RD, et al. JAMA. 2026 Jan 6;335(1):49-59. doi: 10.1001/jama.2025.19808. JAMA. 2026. PMID: 41335448 Clinical Trial.