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. 2025 Dec 2;37(12):2296-2297.
doi: 10.1016/j.cmet.2025.10.018.

Adipose whispers to mast cells for accelerating immune evasion in pancreatic cancer

Lorène Rousseau  1 , Ping-Chih Ho  2
Affiliations

Adipose whispers to mast cells for accelerating immune evasion in pancreatic cancer

Lorène Rousseau et al. Cell Metab. .

Abstract

The mechanisms connecting obesity to pancreatic cancer progression remain poorly defined. A new study reveals that extracellular vesicles from visceral adipose tissue reprogram immune cells through a cathepsin A-pseudouridine-mast cell axis, uncovering how obesity drives immune evasion and resistance to checkpoint blockade therapy in pancreatic cancer.

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Conflict of interest statement

Declaration of interests P.-C.H. is a member of the scientific advisory board and co-founder of Pilatus Biosciences.

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