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. 2025 Dec 3:izaf294.
doi: 10.1093/ibd/izaf294. Online ahead of print.

Evaluating Choice of Biologics for Isolated Small-Bowel Crohn's Disease

June Tome  1 , Saqr Alsakarneh  2 , Jana G Hashash  3 , Francis A Farraye  3 , Darrell S Pardi  1
Affiliations

Evaluating Choice of Biologics for Isolated Small-Bowel Crohn's Disease

June Tome et al. Inflamm Bowel Dis. .
No abstract available

Keywords: Crohn's disease; small bowel; vedolizumab.

Plain language summary

In this study we evaluated the effectiveness of vedolizumab (anti-integrin) vs ustekinumab/risankizumab (anti-interleukin) therapy for isolated small-bowel Crohn’s disease using a real-world, multicenter national database. We found that anti-interleukin therapy was more effective for inducing steroid-free remission and reducing hospitalizations.

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