Editorial Expression of Concern: Munc13 C₂B domain is an activity-dependent Ca²⁺ regulator of synaptic exocytosis

Ok-Ho Shin^#^{1

2}, Jun Lu^#^{3

4}, Jeong-Seop Rhee^#^{5

6

7}, Diana R Tomchick³, Zhiping P Pang^{1

8}, Sonja M Wojcik⁷, Marcial Camacho-Perez^{6

9}, Nils Brose⁷, Mischa Machius³, Josep Rizo^{10

11}, Christian Rosenmund^{12

13

14}, Thomas C Südhof^{15

16

17

18

19}

Affiliations

¹ Departments of Neuroscience, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
² Department of Neuroscience & Cell Biology, University of Texas Medical Branch, Galveston, Texas, USA.
³ Departments of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
⁴ Merck & Co. Inc., Rahway, New Jersey, USA.
⁵ Department of Membrane Biophysics, Max-Planck-Institut für Biophysikalische Chemie, Göttingen, Germany.
⁶ Department of Neuroscience, Baylor College of Medicine, Houston, Texas, USA.
⁷ Department of Molecular Neurobiology, Max-Planck-Institut für Experimentelle Medizin, Göttingen, Germany.
⁸ Department of Molecular & Cellular Physiology, Stanford University, California, USA.
⁹ Department of Molecular & Human Genetics, Baylor College of Medicine, Houston, Texas, USA.
¹⁰ Departments of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas, USA. jose@arnie.swmed.edu.
¹¹ Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas, USA. jose@arnie.swmed.edu.
¹² Department of Membrane Biophysics, Max-Planck-Institut für Biophysikalische Chemie, Göttingen, Germany. rosenmun@bcm.tmc.edu.
¹³ Department of Neuroscience, Baylor College of Medicine, Houston, Texas, USA. rosenmun@bcm.tmc.edu.
¹⁴ Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas, USA. rosenmun@bcm.tmc.edu.
¹⁵ Departments of Neuroscience, University of Texas Southwestern Medical Center, Dallas, Texas, USA. tcs1@stanford.edu.
¹⁶ Department of Molecular & Cellular Physiology, Stanford University, California, USA. tcs1@stanford.edu.
¹⁷ Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas, USA. tcs1@stanford.edu.
¹⁸ Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Texas, USA. tcs1@stanford.edu.
¹⁹ Howard Hughes Medical Institute, Stanford University, Stanford, California, USA. tcs1@stanford.edu.

^# Contributed equally.

PMID: 41339862
DOI: 10.1038/s41594-025-01730-2

Editorial Expression of Concern: Munc13 C₂B domain is an activity-dependent Ca²⁺ regulator of synaptic exocytosis

Ok-Ho Shin et al. Nat Struct Mol Biol. 2025 Dec.

. 2025 Dec;32(12):2634.

doi: 10.1038/s41594-025-01730-2.

Authors

Affiliations

¹ Departments of Neuroscience, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
² Department of Neuroscience & Cell Biology, University of Texas Medical Branch, Galveston, Texas, USA.
³ Departments of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
⁴ Merck & Co. Inc., Rahway, New Jersey, USA.
⁵ Department of Membrane Biophysics, Max-Planck-Institut für Biophysikalische Chemie, Göttingen, Germany.
⁶ Department of Neuroscience, Baylor College of Medicine, Houston, Texas, USA.
⁷ Department of Molecular Neurobiology, Max-Planck-Institut für Experimentelle Medizin, Göttingen, Germany.
⁸ Department of Molecular & Cellular Physiology, Stanford University, California, USA.
⁹ Department of Molecular & Human Genetics, Baylor College of Medicine, Houston, Texas, USA.
¹⁰ Departments of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas, USA. jose@arnie.swmed.edu.
¹¹ Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas, USA. jose@arnie.swmed.edu.
¹² Department of Membrane Biophysics, Max-Planck-Institut für Biophysikalische Chemie, Göttingen, Germany. rosenmun@bcm.tmc.edu.
¹³ Department of Neuroscience, Baylor College of Medicine, Houston, Texas, USA. rosenmun@bcm.tmc.edu.
¹⁴ Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas, USA. rosenmun@bcm.tmc.edu.
¹⁵ Departments of Neuroscience, University of Texas Southwestern Medical Center, Dallas, Texas, USA. tcs1@stanford.edu.
¹⁶ Department of Molecular & Cellular Physiology, Stanford University, California, USA. tcs1@stanford.edu.
¹⁷ Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas, USA. tcs1@stanford.edu.
¹⁸ Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Texas, USA. tcs1@stanford.edu.
¹⁹ Howard Hughes Medical Institute, Stanford University, Stanford, California, USA. tcs1@stanford.edu.

^# Contributed equally.

PMID: 41339862
DOI: 10.1038/s41594-025-01730-2

No abstract available

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Expression of concern for

Munc13 C2B domain is an activity-dependent Ca2+ regulator of synaptic exocytosis.
Shin OH, Lu J, Rhee JS, Tomchick DR, Pang ZP, Wojcik SM, Camacho-Perez M, Brose N, Machius M, Rizo J, Rosenmund C, Südhof TC. Shin OH, et al. Nat Struct Mol Biol. 2010 Mar;17(3):280-8. doi: 10.1038/nsmb.1758. Epub 2010 Feb 14. Nat Struct Mol Biol. 2010. PMID: 20154707 Free PMC article.

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Editorial Expression of Concern: Munc13 C₂B domain is an activity-dependent Ca²⁺ regulator of synaptic exocytosis

Affiliations

Editorial Expression of Concern: Munc13 C₂B domain is an activity-dependent Ca²⁺ regulator of synaptic exocytosis

Authors

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Expression of concern for

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