A vision of chromosome organization

Kaite Zhang^{1

2}, Vijay Ramani^{1

3}

Affiliations

¹ Institute for Data Science and Biotechnology, J. David Gladstone Institutes, San Francisco, CA, USA.
² Tetrad Graduate Program, University of California San Francisco, San Francisco, CA, USA.
³ Department of Biochemistry and Biophysics, University of California, San Francisco, CA, USA.

Comment

Kaite Zhang et al. Science. 2025.

. 2025 Dec 4;390(6777):986-987.

doi: 10.1126/science.aed0014. Epub 2025 Dec 4.

Kaite Zhang^{1

2}, Vijay Ramani^{1

3}

¹ Institute for Data Science and Biotechnology, J. David Gladstone Institutes, San Francisco, CA, USA.
² Tetrad Graduate Program, University of California San Francisco, San Francisco, CA, USA.
³ Department of Biochemistry and Biophysics, University of California, San Francisco, CA, USA.

Abstract

Cryogenic electron tomography of condensed chromatin enables multiscale analysis of its structure.

Multiscale structure of chromatin condensates explains phase separation and material properties.
Zhou H, Huertas J, Maristany MJ, Russell K, Hwang JH, Yao RW, Samanta N, Hutchings J, Billur R, Shiozaki M, Zhao X, Doolittle LK, Gibson BA, Soranno A, Riggi M, Espinosa JR, Yu Z, Villa E, Collepardo-Guevara R, Rosen MK. Zhou H, et al. Science. 2025 Dec 4;390(6777):eadv6588. doi: 10.1126/science.adv6588. Epub 2025 Dec 4. Science. 2025. PMID: 41343645 Free PMC article.