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Review
. 2025 Dec 3:43:101395.
doi: 10.1016/j.preghy.2025.101395. Online ahead of print.

Preconception health as a target for improved pregnancy outcomes: Where do we go from here?

McKenzie K Jancsura  1 , Ira Bernstein  2 , Stefan R Hansson  3 , David E Cantonwine  4 , Keith M Godfrey  5 , Judith Stephenson  6 , Régine Steegers-Theunissen  7 , Shane Norris  8 , Dominik Heider  9 , James M Roberts  10
Affiliations
Review

Preconception health as a target for improved pregnancy outcomes: Where do we go from here?

McKenzie K Jancsura et al. Pregnancy Hypertens. .

Abstract

Preconception health status, especially of women, but also of men, is known to influence pregnancy outcomes. Despite knowledge of the growing importance of preconception health, numerous challenges remain for conducting research in this population and delivering appropriate clinical care. The 2023 Global Pregnancy Collaboration annual workshop focused on exploring preconception health as it relates to adverse pregnancy outcomes. Here we summarize the proceedings and the current state of the science. We particularly focus on quantifying the exposome as a rich target for investigation of factors that increase the risk for and/ or contribute to preeclampsia and other adverse pregnancy outcomes. We conclude with recommendations for the scientific and clinical community to address knowledge gaps regarding the links between preconception health and adverse pregnancy outcomes.

Keywords: Diet; Environment; Exposome; Preconception; Preeclampsia.

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Conflict of interest statement

Declaration of Competing Interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: KMG has received reimbursement for speaking at conferences sponsored by companies selling nutritional products, and is part of an academic consortium that has received research funding from Bayer, Boehringer Ingelheim, Nestec, BenevolentAI Bio Ltd. and Danone. The other authors have no conflicts of interest to disclose.

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