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. 2025 Dec;5(12):1634-1637.
doi: 10.1016/j.jacasi.2025.09.023.

Association of Gut Microbiome Biomarkers With Mortality in Chinese Patients With Acute/Worsening Heart Failure

Toru Suzuki  1 , Hui Ding  2 , Fang Yuan  2 , Yiou Li  2 , Jinqian Ren  3 , Hong Zhan  3 , Muhammad Zubair Israr  4 , Xiangyang Sun  5 , Zhaohui Qiu  2 , Huiming Sheng  6
Affiliations

Association of Gut Microbiome Biomarkers With Mortality in Chinese Patients With Acute/Worsening Heart Failure

Toru Suzuki et al. JACC Asia. 2025 Dec.
No abstract available

Keywords: gut microbiome; heart failure; metabolite.

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Conflict of interest statement

Funding Support and Author Disclosures This work was supported by the following funding: Dr Suzuki: the Japan Heart Foundation, National Institute for Health Research (Leicester Biomedical Research Centre), the British Heart Foundation (BHF) including the Centre of Research Excellence Award (RE/24/130031), the Medical Research Council (MRC) UK Consortium on MetAbolic Phenotyping (MAP/UK), Grant-in-Aid for Scientific Research (A) (23H00454) and for Challenging Research (Pioneering) (22K18412) from the Japan Society for the Promotion of Science (JSPS), and the LeDucq Foundation. Dr Zhan: Shanghai Science and Technology Innovation Action Plan biomedical innovation and development project (No. 24S11902200). Dr Sheng: the National Natural Science Foundation of China (No. 82070730), the Fund of Shanghai Changning District Medical Doctor Innovation Talent Base (RCJD2021B01). The authors have reported that they have no relationships relevant to the contents of this paper to disclose.

Figures

Figure 1
Figure 1
Association of Gut Microbiome Biomarkers With Mortality in Patients With Heart Failure (A) Kaplan-Meier survival curves stratified by the number of elevated gut microbiome biomarkers (0-5). Shaded areas indicate 95% CI; the number of events/deaths are shown below the x-axis. (B) Log-rank tests: chi-square values and P values comparing survival by the number of elevated biomarkers (pairwise comparisons vs 0 elevated and across groups) at 1 year and 3 years. (C) Adjusted HRs with 95% CIs from Cox proportional hazards models for mortality at 1 year and 3 years, comparing 1 to 5 elevated groups with 0 elevated (reference). Models are adjusted for age, sex, B-type natriuretic peptide, and renal function by estimated glomerular filtration rate.
See this image and copyright information in PMC

References

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    1. Suzuki T., Yazaki Y., Voors A.A., et al. Association with outcomes and response to treatment of trimethylamine N-oxide in heart failure: results from BIOSTAT-CHF. Eur J Heart Fail. 2019;21:877–886. - PubMed
    1. Yazaki Y., Salzano A., Nelson C.P., et al. Geographical location affects the levels and association of trimethylamine N-oxide with heart failure mortality in BIOSTAT-CHF: a post-hoc analysis. Eur J Heart Fail. 2019;21:1291–1294. - PubMed
    1. Yazaki Y., Aizawa K., Israr M.Z., et al. Ethnic differences in association of outcomes with trimethylamine N-oxide in acute heart failure patients. ESC Heart Fail. 2020;7:2373–2378. - PMC - PubMed
    1. Israr M.Z., Bernieh D., Salzano A., et al. Association of gut-related metabolites with outcome in acute heart failure. Am Heart J. 2021;234:71–80. - PubMed

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