Funding Support and Author Disclosures TS was supported by the following funding: the Japan Heart Foundation, National Institute for Health Research (Leicester Biomedical Research Centre), the British Heart Foundation (BHF) including the Centre of Research Excellence Award (RE/24/130031), the Medical Research Council (MRC) UK Consortium on MetAbolic Phenotyping (MAP/UK), Grant-in-Aid for Scientific Research (A) (23H00454) and for Challenging Research (Pioneering) (22K18412) from the Japan Society for the Promotion of Science (JSPS), the LeDucq Foundation, and the Cross-ministerial Strategic Innovation Promotion Program (SIP) on “Integrated Health Care System” Grant Number JPJ012425. The author has reported that he has no relationship relevant to the contents of this paper to disclose.