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Review
. 1974 Jan;3(1):69-96.
doi: 10.1111/j.1365-2265.1974.tb03298.x.

Sex-hormone-binding globulin

D C Anderson
Review

Sex-hormone-binding globulin

D C Anderson. Clin Endocrinol (Oxf). 1974 Jan.

Abstract

PIP: A review was made to understand how plasma binding protein might influence sex-hormone action in target tissues. Steroids are predominately bound to plasma proteins and only unbound steroids enter the cells. Sex-hormone-binding globulin (SHBG) binds to both the main circulating steroid T and E2 but changes in SHBG concentrations exert significant results. Increased SHBG levels increase estrogen production and decreases T activity; whereas, increased androgens increase T action and inhibit SHBG production. These disturbances in hormone maintenance may lead to abnormal adult sex differentiation such as hirsutism and forms of hynaecomastia. By developing SHBG concentration measurement methods-responses of hirsutism to glucocorticoid or estrogem may be assessed. In addition, the effect of thyroid hormones on SHBG may also have therapeutic implications in endocrine disease.

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