doi: 10.1016/j.cpsurg.2025.101917.
Epub 2025 Oct 14.
Revolutionizing small bowel transplantation in mice and rats: A cutting-edge dry-lab simulation model
Philipp Seeger
1
, Anas Amin Preukschas
1
, Jöran Lücke
2
, Morsal Sabihi
3
, Pablo Stringa
4
, Natalia Lausada
5
, Jeremias Moreira
6
, Leandro Emmanuel Vecchio Dezillio
7
, Javier Serradilla
7
, Ane Miren Andres Moreno
7
, Francisco Hernández Oliveros
7
, Stephan Bennemann
8
, Andres Machicote
3
, Dimitra E Zazara
9
, Eleftherios D Papazoglou
10
, Baris Mercanoglu
1
, Tarik Ghadban
1
, Michael F Nentwich
11
, Felix Nickel
1
, Oliver Mann
1
, Thilo Hackert
1
, Maria Virginia Gentilini
6
, Jun Oh
12
, Graziano Oldani
13
, Stephanie Chartier-Plante
14
, David Harriman
15
, Karl J Oldhafer
16
, Samuel Huber
3
, Gabriel E Gondolesi
17
, Anastasios D Giannou
18
Affiliations
Affiliations
- 1 Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
- 2 Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Section of Molecular Immunology and Gastroenterology, Hamburg, Germany; Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
- 3 I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Section of Molecular Immunology and Gastroenterology, Hamburg, Germany; Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
- 4 Transplant Group, La Paz University Hospital Health Research Institute (IdiPAZ), Madrid, Spain; Department of Pediatric Surgery, La Paz University Hospital, Madrid, Spain; Institute for Immunological and Pathophysiological Studies (IIFP), School of Exact Sciences, National University of La Plata, National Council of Scientific and Technical Research (CONICET), La Plata, Argentina; Organ Transplant Laboratory, School of Medicine, National University of La Plata, La Plata, Argentina; Microsurgical Research Laboratory, Instituto de Medicina Traslacional, Trasplante y Bioingeniería (IMeTTyB), Favaloro University, Buenos Aires, Argentina.
- 5 Institute for Immunological and Pathophysiological Studies (IIFP), School of Exact Sciences, National University of La Plata, National Council of Scientific and Technical Research (CONICET), La Plata, Argentina; Organ Transplant Laboratory, School of Medicine, National University of La Plata, La Plata, Argentina; Microsurgical Research Laboratory, Instituto de Medicina Traslacional, Trasplante y Bioingeniería (IMeTTyB), Favaloro University, Buenos Aires, Argentina.
- 6 Microsurgical Research Laboratory, Instituto de Medicina Traslacional, Trasplante y Bioingeniería (IMeTTyB), Favaloro University, Buenos Aires, Argentina.
- 7 Transplant Group, La Paz University Hospital Health Research Institute (IdiPAZ), Madrid, Spain; Department of Pediatric Surgery, La Paz University Hospital, Madrid, Spain.
- 8 Faculty of Medicine, Department of Surgery, Transplantation, and Gastroenterology, Semmelweis University, Budapest, Hungary.
- 9 Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf, Hamburg, Germany; University Children's Hospital, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Department of Obstetrics and Fetal Medicine, Division for Experimental Feto-Maternal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
- 10 Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Section of Molecular Immunology and Gastroenterology, Hamburg, Germany.
- 11 Department of Intensive Care Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
- 12 University Children's Hospital, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
- 13 Hepatology and Transplantation Laboratory, Department of Surgery, Faculty of Medicine, University of Geneva, Geneva, Switzerland; Department of Surgery, Division of General Surgery, The University of British Columbia, Vancouver, Canada.
- 14 Department of Surgery, Division of General Surgery, The University of British Columbia, Vancouver, Canada.
- 15 Department of Urologic Sciences, University of British Columbia, Vancouver, Canada.
- 16 Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, Asklepios Hospital Barmbek, Hamburg, Germany; Asklepios Campus Hamburg, Semmelweis University Budapest, Hamburg, Germany.
- 17 Microsurgical Research Laboratory, Instituto de Medicina Traslacional, Trasplante y Bioingeniería (IMeTTyB), Favaloro University, Buenos Aires, Argentina; MedStar Georgetown Transplantation Institute, Georgetown University, Washington, DC.
- 18 Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Section of Molecular Immunology and Gastroenterology, Hamburg, Germany; Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Microsurgical Research Laboratory, Instituto de Medicina Traslacional, Trasplante y Bioingeniería (IMeTTyB), Favaloro University, Buenos Aires, Argentina; Department of Surgery, Division of General Surgery, The University of British Columbia, Vancouver, Canada; Department of Urologic Sciences, University of British Columbia, Vancouver, Canada. Electronic address: a.giannou@uke.de.
- PMID: 41354505
- DOI: 10.1016/j.cpsurg.2025.101917
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Revolutionizing small bowel transplantation in mice and rats: A cutting-edge dry-lab simulation model
Philipp Seeger et al.
Curr Probl Surg.
2025 Dec.
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doi: 10.1016/j.cpsurg.2025.101917.
Epub 2025 Oct 14.
Authors
Philipp Seeger
1
, Anas Amin Preukschas
1
, Jöran Lücke
2
, Morsal Sabihi
3
, Pablo Stringa
4
, Natalia Lausada
5
, Jeremias Moreira
6
, Leandro Emmanuel Vecchio Dezillio
7
, Javier Serradilla
7
, Ane Miren Andres Moreno
7
, Francisco Hernández Oliveros
7
, Stephan Bennemann
8
, Andres Machicote
3
, Dimitra E Zazara
9
, Eleftherios D Papazoglou
10
, Baris Mercanoglu
1
, Tarik Ghadban
1
, Michael F Nentwich
11
, Felix Nickel
1
, Oliver Mann
1
, Thilo Hackert
1
, Maria Virginia Gentilini
6
, Jun Oh
12
, Graziano Oldani
13
, Stephanie Chartier-Plante
14
, David Harriman
15
, Karl J Oldhafer
16
, Samuel Huber
3
, Gabriel E Gondolesi
17
, Anastasios D Giannou
18
Affiliations
- 1 Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
- 2 Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Section of Molecular Immunology and Gastroenterology, Hamburg, Germany; Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
- 3 I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Section of Molecular Immunology and Gastroenterology, Hamburg, Germany; Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
- 4 Transplant Group, La Paz University Hospital Health Research Institute (IdiPAZ), Madrid, Spain; Department of Pediatric Surgery, La Paz University Hospital, Madrid, Spain; Institute for Immunological and Pathophysiological Studies (IIFP), School of Exact Sciences, National University of La Plata, National Council of Scientific and Technical Research (CONICET), La Plata, Argentina; Organ Transplant Laboratory, School of Medicine, National University of La Plata, La Plata, Argentina; Microsurgical Research Laboratory, Instituto de Medicina Traslacional, Trasplante y Bioingeniería (IMeTTyB), Favaloro University, Buenos Aires, Argentina.
- 5 Institute for Immunological and Pathophysiological Studies (IIFP), School of Exact Sciences, National University of La Plata, National Council of Scientific and Technical Research (CONICET), La Plata, Argentina; Organ Transplant Laboratory, School of Medicine, National University of La Plata, La Plata, Argentina; Microsurgical Research Laboratory, Instituto de Medicina Traslacional, Trasplante y Bioingeniería (IMeTTyB), Favaloro University, Buenos Aires, Argentina.
- 6 Microsurgical Research Laboratory, Instituto de Medicina Traslacional, Trasplante y Bioingeniería (IMeTTyB), Favaloro University, Buenos Aires, Argentina.
- 7 Transplant Group, La Paz University Hospital Health Research Institute (IdiPAZ), Madrid, Spain; Department of Pediatric Surgery, La Paz University Hospital, Madrid, Spain.
- 8 Faculty of Medicine, Department of Surgery, Transplantation, and Gastroenterology, Semmelweis University, Budapest, Hungary.
- 9 Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf, Hamburg, Germany; University Children's Hospital, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Department of Obstetrics and Fetal Medicine, Division for Experimental Feto-Maternal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
- 10 Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Section of Molecular Immunology and Gastroenterology, Hamburg, Germany.
- 11 Department of Intensive Care Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
- 12 University Children's Hospital, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
- 13 Hepatology and Transplantation Laboratory, Department of Surgery, Faculty of Medicine, University of Geneva, Geneva, Switzerland; Department of Surgery, Division of General Surgery, The University of British Columbia, Vancouver, Canada.
- 14 Department of Surgery, Division of General Surgery, The University of British Columbia, Vancouver, Canada.
- 15 Department of Urologic Sciences, University of British Columbia, Vancouver, Canada.
- 16 Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, Asklepios Hospital Barmbek, Hamburg, Germany; Asklepios Campus Hamburg, Semmelweis University Budapest, Hamburg, Germany.
- 17 Microsurgical Research Laboratory, Instituto de Medicina Traslacional, Trasplante y Bioingeniería (IMeTTyB), Favaloro University, Buenos Aires, Argentina; MedStar Georgetown Transplantation Institute, Georgetown University, Washington, DC.
- 18 Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Section of Molecular Immunology and Gastroenterology, Hamburg, Germany; Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Microsurgical Research Laboratory, Instituto de Medicina Traslacional, Trasplante y Bioingeniería (IMeTTyB), Favaloro University, Buenos Aires, Argentina; Department of Surgery, Division of General Surgery, The University of British Columbia, Vancouver, Canada; Department of Urologic Sciences, University of British Columbia, Vancouver, Canada. Electronic address: a.giannou@uke.de.
- PMID: 41354505
- DOI: 10.1016/j.cpsurg.2025.101917
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Declaration of competing interest The authors of this manuscript have no conflicts of interest to disclose.
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