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Case Reports
. 2025 Dec 18;15(4):104111.
doi: 10.5500/wjt.v15.i4.104111.

Utilization of normothermic machine perfusion in pediatric liver transplantation: Three case reports

Christine S Hwang  1   2 , Andrew D Shubin  1   3 , Amal Aqul  4 , Jorge A Sanchez-Vivaldi  5 , Kayla M Colvill  6 , Malcolm P MacConmara  7 , Yash Kadakia  8 , Christine Johansen  1   3 , Jigesh A Shah  1   3 , Steven I Hanish  9 , Parsia A Vagefi  1   3 , Madhukar S Patel  1   3
Affiliations
Case Reports

Utilization of normothermic machine perfusion in pediatric liver transplantation: Three case reports

Christine S Hwang et al. World J Transplant. .

Abstract

Background: Normothermic machine perfusion (NMP) utilizing OCS Liver is becoming increasingly common in adult liver transplantation (LT), but not in pediatric transplantation. OCS Liver has been shown to decrease post-reperfusion syndrome and early allograft dysfunction after transplantation. We describe the first case series of three pediatric patients who received a liver transplant using livers preserved with NMP.

Case summary: Three pediatric patients, all with different etiologies of liver disease, were successfully transplanted with livers preserved with NMP. All patients are currently doing well with follow-ups of 7 to 16 months post-transplant.

Conclusion: The use of OCS Liver in pediatric LT is feasible and can be performed even in the sickest recipients with excellent outcomes. Utilization of OCS Liver can optimize donor and recipient factors to allow for optimal outcomes.

Keywords: Case report; Liver transplantation; Normothermic machine perfusion; Pediatrics.

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Conflict of interest statement

Conflict-of-interest statement: Madhukar S. Patel is supported as the Dedman Scholar of Clinical Care at UT Southwestern Medical Center. The funder had no role in design and conduct of the study; collection, management, analysis, and interpretation of the data; or preparation of the manuscript. All authors declare that they have no competing interests.

Figures

Figure 1
Figure 1
Liver function tests post-transplantation. A: Alanine transaminase; B: Aspartate transaminase; C: Total bilirubin; D: International ratio.
Figure 2
Figure 2
Cannulation of pediatric liver for Organ Care System Liver.
See this image and copyright information in PMC

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