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. 2026 Jan 6;335(1):21-24.
doi: 10.1001/jama.2025.21721.

Advancing CAR T-Cell Therapy: Evidence-Based Trial Design for Chimeric Antigen Receptor T-Cell Therapy in Oncology

Upendra Mahat  1 , Asha Das  2 , Vijay Kumar  3 , Vinay Prasad  4
Affiliations

Advancing CAR T-Cell Therapy: Evidence-Based Trial Design for Chimeric Antigen Receptor T-Cell Therapy in Oncology

Upendra Mahat et al. JAMA. .
No abstract available

Plain language summary

This Viewpoint discusses the recent decision by the US Food and Drug Administration to eliminate Risk Evaluation and Mitigation Strategies requirements for chimeric antigen receptor (CAR) T-cell therapies for the treatment of cancer.

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