Restoring fertility with a lipid nanoparticle-mRNA platform: A new era in male germline therapy

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Comment

Yuka Kitamura et al. Proc Natl Acad Sci U S A. 2025.

. 2025 Dec 16;122(50):e2527314122.

doi: 10.1073/pnas.2527314122. Epub 2025 Dec 8.

¹ Department of Microbiology and Molecular Genetics, University of California, Davis, CA 95616.

No abstract available

Conflict of interest statement

Competing interests statement:The authors declare no competing interest.

Sperm and offspring production in a nonobstructive azoospermia mouse model via testicular mRNA delivery using lipid nanoparticles.
Mashiko D, Emori C, Hatanaka Y, Motooka D, Pan C, Kaneda Y, Matzuk MM, Ikawa M. Mashiko D, et al. Proc Natl Acad Sci U S A. 2025 Oct 21;122(42):e2516573122. doi: 10.1073/pnas.2516573122. Epub 2025 Oct 13. Proc Natl Acad Sci U S A. 2025. PMID: 41082659 Free PMC article.

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