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Case Reports
. 2025 Oct 23:67:85-88.
doi: 10.1016/j.jdcr.2025.09.019. eCollection 2026 Jan.

Graham-Little-Piccardi-Lassueur syndrome: A rare case associated with a chromosomal anomaly and unusual histopathologic characterization of keratosis pilaris-like lesions

Timothy Klufas  1   2 , Ayushya Ajmani  3 , Albert Zhou  2 , Campbell L Stewart  2 , Brett Sloan  2 , Gillian Weston  2
Affiliations
Case Reports

Graham-Little-Piccardi-Lassueur syndrome: A rare case associated with a chromosomal anomaly and unusual histopathologic characterization of keratosis pilaris-like lesions

Timothy Klufas et al. JAAD Case Rep. .
No abstract available

Keywords: Alopecia; Chromosome 8 Duplication/Deletion; GLPLS; Graham-Little-Piccardi-Lassueur Syndrome; Keratosis PilarisLichen Planopilaris; LPP.

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Conflict of interest statement

None disclosed.

Figures

Fig 1
Fig 1
Diffuse patchy hair loss on the vertex, midline, and fronto-temporal scalp with perifollicular erythema (A). Multiple follicular papules on left upper arm clinically reminiscent of keratosis pilaris (B).
Fig 2
Fig 2
Punch biopsy of the scalp showing decreased follicular density (A) replacement of follicles by fibrous tracts. Perifollicular inflammation with dyskeratosis and epithelial atrophy and fibrosis affects the remaining follicles (B).
Fig 3
Fig 3
Punch biopsy of the right shoulder demonstrates a dilated follicle at the level of the infundibulum with a keratotic plug with surrounding perifollicular and perivasulcar inflammation (A). The follicle is ruptured with extrusion of hair shafts into the adjacent superficial reticular dermis (B).
See this image and copyright information in PMC

References

    1. Alkhayal F.A., Alsudairy F., Al Mubarak L., Almohanna H.M. Graham-little piccardi lassueur syndrome and review of the literature. Clin Case Rep. 2021;9(9) doi: 10.1002/ccr3.4761. - DOI - PMC - PubMed
    1. Pai V.V., Kikkeri N.N., Sori T., Dinesh U. Graham-little piccardi lassueur syndrome: an unusual variant of follicular Lichen planus. Int J Trichology. 2011;3(1):28–30. doi: 10.4103/0974-7753.82129. - DOI - PMC - PubMed
    1. Smaha K.M., Madray V.M., Powell M.R., Davis L.S. Graham little-piccardi-lassueur syndrome with unique distribution in a man with autoimmune disease. JAAD Case Rep. 2024;52:49–51. doi: 10.1016/j.jdcr.2024.07.016. - DOI - PMC - PubMed
    1. Celen A., Lo Sicco K., Lee N., Meehan S., Weed J. Graham-little-piccardi-lasseur syndrome: a case report. J Drugs Dermatol. 2023;22(2):210–216. doi: 10.36849/JDD.6926. - DOI - PubMed
    1. Takahagi S., Tanaka A. A case of graham-little-piccardi-lasseur syndrome successfully treated with minocycline. Acta Derm Venereol. 2024;104 doi: 10.2340/actadv.v104.40008. - DOI - PMC - PubMed

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